Covariate Model Selection Approaches for Population Pharmacokinetics…
2 天之前 · Population pharmacokinetic models are mathematical models describing the time course of drug concentrations, usually in plasma. ... or sampling design used in this study. To …
“Population pharmacokinetic analysis, using non-linear mixed effects models, is an appropriate methodology for obtaining pharmacokinetic information in paediatric trials both from a practical …
A pragmatic approach to the design of population pharmacokinetic studies
2005年10月5日 · Pragmatic designs that achieve high efficiency in the estimation parameters should be used in the design of population PK studies, and simulation should be used to …
A pragmatic approach to the design of population pharmacokinetic studies
2005年10月5日 · The publication of a seminal article on nonlinear mixed-effect modeling led to a revolution in pharmacokinetics (PKs) with the introduction of the population approach. Since …
Methods and software tools for design evaluation in population ...
We compared and evaluated the following five software tools: PFIM, PkStaMp, PopDes, PopED and POPT. The comparisons were performed using two models, a simple-one compartment …
Simulation-Based Pharmacokinetics Sampling Design for Evaluating ...
2021年6月28日 · We address sampling design of population pharmacokinetics (popPK) experiments in the context of two phase 2b efficacy trials that evaluate the efficacy of VRC01 …
Investigator‐Initiated Clinical Pharmacokinetic Studies in …
2025年1月14日 · The sampling schedule in a clinical pharmacology study is determined by the study design and the specific research questions being addressed. Generally, two standard …
Simulations and optimal design methods can maximize the utility of population PK data collection and analyses. For exampl e, the trial sample size and PK sampling schedule can be
Drug models describe the relationship between exposure (or pharmacokinetics), response (or pharmacodynamics) for both desired and undesired effects, and individual patient …
Dosing and route of administration of clindamycin given in …
4 天之前 · Trial design and PK sampling. Each syringe represents a blood sample. Blood samples were immediately centrifuged, and plasma samples stored at -20°C until analysis. ... A …