The tumor suppressor LKB1 regulates starvation-induced autophagy under ...
2017年8月4日 · We demonstrate that the autophagy defect in lkb1 mutants can be partially rescued by inhibiting mTOR signaling but not by inhibiting the PI3K pathway. Interestingly, …
LKB1 biology: assessing the therapeutic relevancy of LKB1 …
2024年6月6日 · Liver Kinase B1 (LKB1), encoded by Serine-Threonine Kinase 11 (STK11), is a master kinase that regulates cell migration, polarity, proliferation, and metabolism through …
Inhibition of autophagy and MEK promotes ferroptosis in Lkb1 …
2023年1月26日 · Autophagy, an intracellular nutrient scavenging pathway, compensates for Lkb1 loss to support Kras-driven lung tumor growth. Here we preclinically evaluate the possibility of …
Redefining the role of AMPK in autophagy and the energy stress …
2023年5月24日 · We found that glucose starvation suppresses amino acid starvation-induced stimulation of ULK1-Atg14-Vps34 signaling via AMPK activation. During an energy crisis …
LKB1/AMPK Pathway and Drug Response in Cancer: A Therapeutic ...
Autophagy inhibition in LKB1-proficient tumors can be achieved with chloroquine, with some anticancer effects. However, blockade of lysosomal acidification does not impede engulfment …
LKB1 regulates autophagy through AMPK/TOR signaling pathway …
2024年4月1日 · The results from qRT-PCR, WB, flow cytometry, and electron microscopy observations of cell ultrastructure all indicate that silencing LKB1 can inhibit the level of …
Autophagy modulates lipid metabolism to maintain metabolic flexibility ...
2019年2月1日 · Autophagy is a protective process involving self-cannibalization to maintain cellular energy homeostasis during nutrient deprivation. We developed a mouse model for …
Autophagy compensates for Lkb1 loss to maintain adult mice
2020年11月25日 · Liver kinase B1 (LKB1), also known as serine/threonine kinase 11 (STK11) is the major energy sensor for cells to respond to metabolic stress. Autophagy degrades and …
LKB1 regulates autophagy through AMPK/TOR signaling pathway …
2024年4月1日 · The results revealed a significantly up-regulated of LvLKB1 mRNA expression in the hepatopancreas at 3–24 h post-infection with V. alginolyticus (Fig. 1A, p < 0.05). …
m6A mRNA Methylation Regulates LKB1 to Promote Autophagy …
In conclusion, we showed that the WTAP/LKB1/AMPK axis in HCC cells acted as a key regulator, linking m 6 A with autophagy. WTAP-mediated m 6 A modification plays an important role in …