The malaria-infected red blood cell: Structural and functional …
The asexual stage of malaria parasites of the genus Plasmodium invade red blood cells of various species including humans. After parasite invasion, red blood cells progressively acquire a new set of properties and are converted into more typical, ...
Beyond the microcirculation: sequestration of infected red blood cells ...
2024年3月16日 · Sequestration of infected red blood cells (iRBCs) in the microcirculation is a hallmark of cerebral malaria (CM) in post-mortem human brains. It remains controversial how this might be linked to...
The Plasmodium falciparum-infected red blood cell
2011年6月1日 · Plasmodium falciparum, the most virulent of the human malaria parasites, causes up to one million deaths per year. The parasite spends part of its lifecycle inside the red blood cells (RBCs) of its host. As it grows it ingests the RBC cytoplasm, digesting it in an acidic vacuole.
Malaria and the Red Cell - American Society of Hematology
2002年1月1日 · Red blood cells are destroyed as parasites complete their growth cycle, although some parasites may be removed from erythrocytes as immature ring forms by phagocytic cells. 11 Infected erythrocytes may also be phagocytosed by macrophages following opsonization by immunoglobulins and/or complement components. Other effector cells and mechanisms ...
Malaria and Human Red Blood Cells - PMC - PubMed Central (PMC)
Red cells infected by mature forms of P. falciparum become adhesive for a number of different cell types including vascular endothelial cells (cytoadherence), platelets and other infected or non-infected red cells [24–26]. From the parasites’ standpoint, imparting an adhesive phenotype on the red blood cells in which they reside is the key ...
The malaria-infected red blood cell: structural and functional
The asexual stage of malaria parasites of the genus Plasmodium invade red blood cells of various species including humans. After parasite invasion, red blood cells progressively acquire a new set of properties and are converted into more typical, although still simpler, eukaryotic cells by …
The malaria parasite Plasmodium falciparum in red blood cells ...
2020年4月15日 · The malaria parasite Plasmodium falciparum is a protozoan that develops in red blood cells (RBCs) and requires various host factors. For its development in RBCs, nutrients not only from the RBC cytosol but also from the extracellular milieu must be acquired.
Sequestration and Tissue Accumulation of Human Malaria …
2010年9月30日 · This adherence of infected red blood cells (irbcs) to host tissue, also known as sequestration, occurs in small capillaries and post-capillary venules of specific organs such as the brain and lungs. Sequestration has been correlated with mechanical obstruction of blood flow in small blood vessels and vascular endothelial cell activation, which ...
Quantifying the deformability of malaria-infected red blood cells …
Using this new method, we uncover significant differences between the deformability of RBCs infected with different strains of Plasmodium falciparum, providing clues to the variation in virulence of these strains.
Malaria infected red blood cells release small regulatory RNAs …
2018年1月17日 · Cell communication between parasites is an important mechanism to control population density and differentiation. The infected red blood cells (iRBCs) release small extracellular vesicles (EVs)...