What We Know and What We Need to Know about Aromatic and …
Biogenic amines derived from basic and aromatic amino acids (B/A-BAs), polyamines, histamine, serotonin, and catecholamines are a group of molecules playing essential roles in many relevant physiological processes, including cell proliferation, immune response, nutrition and reproduction.
Metabolism and biomarkers of heterocyclic aromatic amines in …
2021年7月21日 · Heterocyclic aromatic amines (HAAs) form during the high-temperature cooking of meats, poultry, and fish. Some HAAs also arise during the combustion of tobacco. HAAs are multisite carcinogens in rodents, inducing cancer of the liver, gastrointestinal tract, pancreas, mammary, and prostate glands.
Aromatic Amine - an overview | ScienceDirect Topics
Aromatic amines represent one of the most important classes of industrial and environmental chemicals. Many aromatic amines have been reported to be powerful carcinogens and mutagens, and/or hemotoxicants. Exposure to aromatic amines occurs in different industrial and agricultural activities as well as in tobacco smoking.
Some Aromatic Amines, Organic Dyes, and Related Exposures.
Metabolic activation was the leading concept to find out how aromatic amines cause biological effects. both acute and chronic toxicity are held to depend on the metabolic activation of the amino group. The key reaction responsible for all the biological activities is the N -oxidation to aryl- N -hydroxylamines.
Aromatic Amino Acids: Biosynthesis, Structure, and Functions
2024年10月24日 · Explore the biosynthesis, structural roles, and metabolic functions of aromatic amino acids in biological systems. Aromatic amino acids, including phenylalanine, tyrosine, and tryptophan, are essential components in the biochemistry of living organisms.
Metabolism of Aromatic Amines | Aromatic Amines: An …
Activation of the free amine group of an aromatic amine results in the metabolic hydroxylation of the aromatic ring (C-hydroxylation). The positions attacked generally correspond to the regions of highest electron density (Weisburger and Weisburger, 1958~.
Novel, unifying mechanism for aromatic primary- amines …
Aromatic primary- amines (APAs) display physiological activity in various areas, including therapeutics, carcinogens and toxicants. More familiar examples include. dapsone, sulfa drugs and procaineamide. Diverse mechanisms have been proposed for these agents.
A New Automated Method for the Analysis of Aromatic Amines …
2019年1月1日 · During smoke inhalation, AAs are first carried into the bloodstream from the lungs, metabolized by the liver, then travels to the bladder to be eventually excreted out of the body through urination.
A biosynthetic pathway to aromatic amines that uses glycyl ... - Nature
2021年11月1日 · Aromatic amines in nature are typically installed with Glu or Gln as the nitrogen donor. Here we report a pathway that features glycyl-tRNA instead.
A Beginner’s Guide to Amines: What are they and Why are they …
Amines are a class of organic compounds that contain a nitrogen atom bonded to one or more alkyl or aromatic groups. They are derivatives of ammonia, where one or more of the hydrogen atoms have been replaced by alkyl or aromatic groups.