489590: p53 Mutation Analysis by Sequencing - Labcorp
Mutations and deletions in p53 predict poor survival in B-CLL patients (median survival 6-31 months) versus those patients without p53 abnormalities (median survival of patients with normal karyotype >100 months).
TP53 Mutation Analysis | NeoGenomics Laboratories
TP53 mutations are detected in at least 50% of all adult tumors and are generally associated with a poor prognosis. For patients with chronic lymphocytic leukemia (CLL), TP53 sequencing, in addition to FISH for 17p deletion, aids in prognosis and/or therapy selection.
P53CA - Overview: Hematologic Neoplasms, TP53 Somatic Mutation…
Provides information regarding the medical device classification for laboratory test kits and reagents.
489590 P53 Mutation Analysis | Labcorp Oncology
The assay can detect a mutation present in at least 20% of a B-cell-enriched sample. False positive or negative results may occur for reasons that include genetic variants, blood transfusions, or somatic heterogeneity of the tissue sample.
TP53 Somatic Mutation, Prognostic | ARUP Laboratories Test …
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Human p53 ELISA Kit - Invitrogen - Thermo Fisher Scientific
The Human p53 solid-phase sandwich ELISA (enzyme-linked immunosorbent assay) is designed to measure the amount of the target bound between a matched antibody pair. A target-specific antibody has been pre-coated in the wells of the supplied microplate.
Human p53 Assay Kit - Indigo Biosciences
This is an all-inclusive cell-based luciferase reporter assay kit targeting the Human Tumor Protein p53 (p53). INDIGO’s p53 reporter assay utilizes proprietary mammalian cells that have been engineered to provide constitutive expression of the Human Tumor Protein p53.
p53 Transcription Factor Assay Kit (Colorimetric) - Abcam
Many solid tumors contain defective forms of p53 that are unable to stop cells from proliferating when, for example, their DNA has been damaged. Therefore, p53 functions to selectively destroy stressed or abnormal cells, thereby protecting the organism from cancer development.
This panel combines wild-type p53 cell lines with mutant p53 cell lines that carry hotspot mutations in one of the following codons: 175, 248, 249, or 273. The p53 status of each line was sequenced and validated by ATCC.
p53 | NeoGenomics Laboratories
The product of the p53 gene is a nuclear phosphoprotein that regulates cell proliferation. Excess accumulation of the mutant p53 gene product results in inactivation of its tumor suppressor function and cellular transformation.
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