Th17/Treg细胞免疫平衡的相关调控机制研究进展
免疫系统可识别、抵抗病原微生物及清除体内异常分裂的细胞，平衡的免疫系统对维持正常的机体反应活动至关重要。人体内的多种细胞都可参与维持免疫稳态，其中辅助性T淋巴细 …
NLRP3-mediated IL-1β in regulating the imbalance between Th17 and Treg ...
2024年8月13日 · All data strongly suggest that the NLRP3 inflammatory influence Th17 cell development and the conversion of Treg cells into Th17 cells through IL-1β, disrupting the …
Regulatory T cells vs Th17: differentiation of Th17 versus Treg, are ...
Naive CD4+ cells differentiate into T helper (Th1, Th2, Th9, Th17) and regulatory T (Treg) cells to execute their immunologic function. Whereas TGF-β suppresses Th1 and Th2 cell …
Metabolic control of the Treg/Th17 axis - PMC - National Center …
Reported and potential mechanisms for the regulation of the Th17/Treg balance by HIF-1. HIF-1 is upregulated in naïve Cd4 + T cells by a range of stimuli including TCR stimulation, LPS, …
Therapeutic Potential of Targeting the Th17/Treg Axis in …
2017年1月14日 · Therapeutic tools targeting Th17-cell cytokines, cytokine receptors and transcription factor pathways facilitate correction of the Th17/Treg imbalance in favor of the …
Intricacies of TGF-β signaling in Treg and Th17 cell biology
2023年5月23日 · Emerging evidence suggests a broad function for the TGF-β superfamily in Treg and Th17 cell biology. TGF-β superfamily signaling pathways crosstalk and interact with a …
When worlds collide: Th17 and Treg cells in cancer and ... - Nature
2018年3月21日 · Th17 cells are vital for host defense against pathogens but have also been implicated in causing autoimmune disorders and cancer, though their role in carcinogenesis is …
Transcriptional and posttranslational regulation of Th17/Treg …
Restoring Th17/Treg balance by modifying the enzymatic activities of RORγt and FOXP3 binding partners may be therapeutically applied to treat severe immune disorders. In this review, we …
Transcriptional and posttranslational regulation of Th17/Treg …
2021年7月28日 · In this review, we focus on the transcriptional and posttranslational regulations of Th17/Treg balance, immune disorders caused by Th17/Treg imbalance, and new …
Research progress of targeted therapy regulating Th17/Treg …
In this review, the potential roles of Th17, Treg, and Th17/Treg imbalance in regulating bone remodelling in RA and PMOP have been summarised, and the potential mechanisms by which …