Topoisomerase - Wikipedia
Summary of topoisomerase types and catalytic mechanisms. The topoisomerases are categorized based on whether they catalyze single- (type I) or double-stranded (type II) DNA breaks. The …
Topoisomerase: Types, Structure, Functions, Mechanism
2023年2月27日 · Topoisomerase is an essential enzyme that aids in the DNA replication process, segregation of chromosomes, transcription, and also in recombination. It was first found by …
DNA topoisomerases: structure, function, and mechanism
In recent years, the crystal structures of a number of topoisomerase fragments, representing nearly all the known classes of enzymes, have been solved. These structures provide …
Topoisomerase – Definition, Types, Structure, and Functions
2023年11月25日 · Topoisomerase, especially type II B enzymes, resolves these structures, prevents DNA damage, and ensures stability. These roles of topoisomerases allow cells to …
Human topoisomerases and their roles in genome stability and
2022年2月28日 · Topoisomerase 1 (TOP1) directly binds the carboxyl terminus domain (CTD) of Pol II (dashed arrows) and is activated by bromodomain-containing protein 4 (BRD4), which …
Cellular roles of DNA topoisomerases: a molecular perspective
2002年6月1日 · This reports the discovery of the first DNA topoisomerase, and proposes the transesterification mechanism of DNA strand breakage and rejoining.
All tangled up: how cells direct, manage and exploit topoisomerase ...
Topoisomerase activity is indispensible to cells, but requires the transient breakage of DNA strands. This property has been exploited, often for significant clinical benefit, by various …
Topoisomerase I in Human Disease Pathogenesis and Treatments
Mammalian topoisomerase 1 (TOP1) is an essential enzyme for normal development. TOP1 relaxes supercoiled DNA to remove helical constraints that can otherwise hinder DNA …
Diversity and Functions of Type II Topoisomerases - PMC
DNA gyrase and topoisomerase IV are the targets for many antibiotics that, according to their mechanism of action, may be divided into two groups: poisons and catalytic inhibitors. Poisons …
Topoisomerase - an overview | ScienceDirect Topics
Topoisomerase is an important enzyme that maintains the topology of DNA by releasing strain developed in the DNA due to its over or under winding during the process of transcription, …