T cell reactivity to the SARS-CoV-2 Omicron variant is preserved …
T cells from most SARS-CoV-2 infected and/or vaccinated individuals have preserved reactivity to the Omicron variant, and their reactivity is enhanced by booster vaccination. However, ∼20% of individuals have reduced T cell recognition of the Omicron spike, potentially due to escape of HLA class I-restricted epitopes.
Structural and functional characterizations of infectivity ... - Cell Press
2022年3月3日 · Preliminary data suggest that the Omicron variant escapes almost all clinically approved antibody therapeutics, significantly impairs humoral immunity elicited by natural infection and vaccination, and possesses higher transmission rates among household contacts than those of the Delta variant, attributing to a higher risk of yet another resurge...
T cell reactivity to the SARS-CoV-2 Omicron variant is preserved …
2022年3月17日 · • “The SARS-CoV-2 Omicron variant demonstrates substantial escape from neutralizing antibody responses (Garcia-Beltran et al., 2021b; Hoffmann et al., 2021)” now refers to Garcia-Beltran et al. (2022). The journal apologizes for any confusion these errors may have caused. DOI: https://doi.org/10.1016/j.cell.2022.03.022. © 2022 The Author (s).
Up or down: where comes Omicron? | Cell Research - Nature
2022年5月31日 · Recent works published in Cell Research and Science reveal the molecular basis of increased transmissibility of Omicron BA.1 and BA.2 and their possible mouse origin. SARS-CoV-2 Omicron...
SARS-CoV-2 Omicron is an immune escape variant with an altered cell …
2022年7月7日 · In this study, we investigate the antigenic and biological properties of the Omicron variant that might underlie immune evasion and increased transmission of the virus using in vitro assays and...
SARS-CoV-2 Omicron variant: recent progress and future …
2022年4月28日 · In this review, we summarized the recent progress in research on the characteristics of the Omicron variant, including its enhanced infectivity and transmissibility, reduced pathogenicity, and...
SARS-CoV-2 Omicron subvariants progressively adapt to human cells …
2024年8月27日 · Our results show that the Omicron variant progressively adapts to human cells through continuous endosome-mediated host cell entry. SARS-CoV-2, the causative agent of coronavirus disease 2019, has evolved into a number of variants/subvariants, which have generated multiple global waves of infection.
Understanding Omicron: Transmissibility, immune evasion and …
2022年5月11日 · Here, we will comment on host cell interactions governing cell entry of the Omicron variant and their implications for transmissibility, virulence, immune evasion, and therapeutic options. Our focus will be on the viral spike (S) protein, which facilitates viral entry into cells and is the key target of the neutralizing antibody response.
Vaccine protection against the SARS-CoV-2 Omicron variant ... - Cell …
2022年4月28日 · In this study, we show that the mRNA-based BNT162b2 vaccine and the adenovirus-vector-based Ad26.COV2.S vaccine provide robust protection against high-dose challenge with the SARS-CoV-2 Omicron variant in cynomolgus macaques. We vaccinated 30 macaques with homologous and heterologous prime …
SARS-CoV-2 Omicron Variant Binds to Human Cells More …
2022年6月20日 · We demonstrated that N440K, T478K, E484A, Q493R, and Q498R mutations play a crucial role in the high binding affinity of Omicron to human cells. After a detailed analysis of residues located at the human cell–virus interface, we predict that the emergence of a new variant with a higher infection rate compared to that of Omicron is still possible.