Understanding the development of Th2 cell-driven allergic airway ...
In particular, the activation of allergen-specific helper T cells towards a type 2 (Th2) phenotype during the first encounters with the allergen, also known as the sensitization phase, is the leading cause of the subsequent development of allergic disease.
Th2A cells: The pathogenic players in allergic diseases - PMC
Proallergic type 2 helper T (Th2A) cells are a subset of memory Th2 cells confined to atopic individuals, and they include all the allergen-specific Th2 cells. Recently, many studies have shown that Th2A cells characterized by CD3+ CD4+ HPGDS+ ...
Th2 Cells in Health and Disease - PubMed
2017年4月26日 · Th2 cells produce IL-4, IL-5, and IL-13, which are important in humoral immunity and protection from helminth infection and are central to the pathogenesis of many allergic inflammatory diseases. Molecular analysis of Th2 cell differentiation and maintenance of function has led to recent discoveries that have refined our understanding of Th2 ...
Th2A cells: The pathogenic players in allergic diseases
2022年8月8日 · Recently, many studies have shown that Th2A cells characterized by CD3 + CD4 + HPGDS + CRTH2 + CD161 high ST2 high CD49d high CD27 low play a crucial role in allergic diseases, such as atopic dermatitis (AD), food allergy (FA), allergic rhinitis (AR), asthma, and eosinophilic esophagitis (EoE).
TH2 cell development and function | Nature Reviews Immunology
2017年10月30日 · T helper 2 (TH2) cells orchestrate protective type 2 immune responses, such as those that target helminths and facilitate tissue repair, but also contribute to chronic inflammatory...
Pathogenic Effector Th2 Cells in Allergic Eosinophilic Inflammatory Disease
2017年10月6日 · As such, peTh2 cells are a potential target in the treatment of allergic eosinophilic inflammation. This review examines peTh2 cells, both in mouse models and human disease, with an emphasis on their role in the pathogenesis of allergic eosinophilic inflammation.
Th2 cells and macrophages cooperatively induce allergic …
2021年3月4日 · Antigen-specific Th2 cells cause allergic diseases, such as asthma, rhinitis, and atopic dermatitis, by producing Th2 cytokines (IL-4, IL-5, and IL-13). Antigen-specific Th2 cells generally exist as memory Th2 cells in vivo, and become activated and mediate allergic inflammation immediately after exposure to specific antigens [19–21].
Sensing of protease activity as a triggering mechanism of Th2 cell ...
2023年9月21日 · CD4 T-helper cell type 2 (Th2) cells mediate host defense against extracellular parasites, like helminths. However, Th2 cells also play a pivotal role in the onset and progression of allergic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma, and …
TH2, allergy and group 2 innate lymphoid cells - Nature
2013年5月20日 · These group 2 or type 2 innate lymphoid cells (ILC2 cells) represent a critical source of type 2 cytokines in vivo and serve an important role in orchestrating the type 2 response to helminths and...
T-helper cell type-2 regulation in allergic disease - PubMed
2021年12月5日 · Substantial experimental evidence now supports the notion that allergic diseases are characterised by a skewing of the immune system towards a T-helper cell type-2 (Th2) phenotype. Studies using both human and mouse model systems have provided key evidence for the role that Th2 cytokines play in dri …