T Cells and Regulated Cell Death: Kill or Be Killed - PubMed
T cells serve as major actors in the adaptive immune response and function by selectively killing cells which are infected or dysfunctional. This feature is highly involved during homeostatic maintenance, and is relied upon and modulated in the context of cancer immunotherapy.
Cytotoxic T cells are able to efficiently eliminate cancer cells by ...
2021年9月1日 · Lethal hit delivery by cytotoxic T lymphocytes (CTL) towards B lymphoma cells occurs as a binary, “yes/no” process. In non-hematologic solid tumors, however, CTL often fail to kill target cells...
Efficient tumor killing and minimal cytokine release with novel T-cell …
In the past decade, exciting cancer treatments have emerged that leverage the potent tumor killing activity of cytotoxic T-cells, including chimeric antigen receptor T-cell (CAR-T) therapies and T-cell-engaging bispecific antibodies (T-BsAbs).
Cytotoxic CD8 + T cells in cancer and cancer immunotherapy
2020年9月15日 · Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of current successful cancer immunotherapies.
T cells as killers - Nature
2022年12月6日 · The cytotoxic (killing) function of T cells is central to their activity in immune defence — for example in eliminating infected or cancerous cells — but it was not until 1970 that cytotoxic...
Cell death plays two major complementary roles in T cell biology: mediating the removal of cells that are targeted by T cells and the removal of T cells themselves. T cells serve as major actors in the adaptive immune response and function by selectively killing cells which are infected or …
Mechanisms and Dynamics of T Cell-Mediated Cytotoxicity In Vivo
2017年6月1日 · Killing of harmful cells by cytotoxic T lymphocytes (CTLs) can cure cancer and infections by intracellular pathogens but is not always achieved. Therefore, understanding the mechanisms that limit T cell-mediated killing in vivo is of critical importance.
Mechanisms and Dynamics of T Cell-Mediated Cytotoxicity
2017年5月9日 · Killing of harmful cells by cytotoxic T lymphocytes (CTLs) can cure cancer and infections by intracellular pathogens but is not always achieved. Therefore, understanding the mechanisms that limit T cell-mediated killing in vivo is of critical importance.
Mito warriors: how T cell assassins reload their weapons to kill …
2021年10月14日 · Cambridge researchers have discovered how T cells – an important component of our immune system – are able to keep on killing as they hunt down and kill cancer cells, repeatedly reloading their toxic weapons. T cells are trained assassins that are sent on their deadly missions by the immune system.
T Cells and Regulated Cell Death: Kill or Be Killed
2019年1月1日 · This review will focus on the role of cell death regulation in the maintenance of T cell homeostasis, as well as T cell-mediated elimination of infected or dysfunctional cells, and will summarize and discuss the current knowledge of the cellular mechanisms which are implicated in these processes.
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