Umbelliferone alleviates impaired wound healing and skin barrier ...
2024年10月4日 · In this study, we examined the effects of umbelliferone on skin wound healing using dermal fibroblasts and skin tissues from a type 2 diabetic mouse model. Our results demonstrate that umbelliferone enhances several crucial aspects of wound healing.
Umbelliferone loaded PEGylated liposomes: preparation, …
Umbelliferone (UB) is a phenylpropanoid-based pharmacologically active agent with promising anti-tumor activities. ... Following treatments, the cell was incubated with 0.01 ml AO/EtBr staining solution. The stained cells were observed and photographed using a fluorescence microscope with a 20 × objective (Olympus, Japan). Experimental solid ...
The Antivirulence Activity of Umbelliferone and Its Protective …
2022年9月22日 · Histopathological analysis for selected tissues from various groups. Umbelliferone alleviated A. hydrophila-induced heart (A), spleen (B), and hepatopancreas (C,D) injury in grass carps. The sections were stained with H&E. Cardiomyocytes were dispersed (black star), deposited hemosiderin granules in the spleen (white arrows), apparent ...
Umbelliferone reduces the expression of inflammatory chemokines in ...
2019年10月1日 · Umbelliferone inhibits total serum levels of IgE, Ig G1, and Ig G2a in DNCB/DFE-induced mouse model. Umbelliferone regulates MAPK, NF-κB, and STAT1 signaling pathways. Umbelliferone reduces pro-inflammatory cytokines and chemokines in vitro and in vivo.
Anti-inflammatory and antioxidant effects of umbelliferone in …
2015年9月4日 · Inflammation is associated with various types of acute and chronic alcohol liver diseases. In this study, we examined whether umbelliferone (7-hydroxycoumarin, UF) ameliorates chronic alcohol-induced liver damage by modulating …
Umbelliferone alleviates hepatic ischemia/reperfusion-induced …
2021年7月15日 · Liver specimens were stored in 10% buffered formalin for 48 h, dehydrated using ascending grades of alcohol, and embedded in paraffin. Specimens were cut into 5-μm thickness sections then stained with Periodic Acid Schiff (PAS) and Hematoxylin and Eosin (H&E) according to the routine examination method of Bancroft and Gamble . The obtained ...
Umbelliferone and Its Synthetic Derivatives as Suitable ... - MDPI
2023年12月15日 · Umbelliferone (UMB), known as 7-hydroxycoumarin, hydrangine, or skimmetine, is a naturally occurring coumarin in the plant kingdom, mainly from the Umbelliferae family that possesses a wide variety of pharmacological properties. In addition, the use of nanoparticles containing umbelliferone may improve anti-inflammatory or anticancer therapy.
Anti-inflammatory and proapoptotic effects of umbelliferone in …
2015年12月11日 · Umbelliferone acts as an anti-inflammatory factor and reduced the mast cell recruitment and reduced the cell proliferation that was confirmed by AgNOR staining. On the other hand, umbelliferone can induce apoptosis by modulating the expressions of Bax, Bcl-2, caspase 3, and caspase 9.
Umbelliferone: Sources, chemistry and bioactivities review
2017年12月1日 · Umbelliferone is a fluorescing compound used as a sunscreen agent. It is synthesized using the Pechmann condensation reaction of resorcinol and formyl acetic acid. Biosynthetically it is synthesized using the phenylpropanoid pathway. Umbelliferone is a synthon for other coumarins and heterocycles with improved biological activities.
Distribution of superoxide and hydrogen peroxide in
2007年1月26日 · Umbelliferone and Mn-DFA activated the production of H 2 O 2 or the conversion of HPF into fluorescein, while esculetin, superoxide dismutase, KI, SHAM or DPI had more or less inhibitory effects.
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