Alternative splicing - Wikipedia
Alternative splicing, or alternative RNA splicing, or differential splicing, is an alternative splicing process during gene expression that allows a single gene to produce different splice variants. For example, some exons of a gene may be included within or …
The physiology of alternative splicing - Nature
2022年10月13日 · Alternative splicing is a substantial contributor to the high complexity of transcriptomes of multicellular eukaryotes. In this Review, we discuss the accumulated evidence that most of this...
Alternative splicing as a regulator of development and tissue …
Alternative splicing expands proteome complexity by generating multiple transcript (and protein) isoforms from a single gene. Numerous alternative splicing events occur during cell differentiation and tissue maturation, suggesting that alternative splicing supports proper development.
Alternative Splicing- Definition, Mechanism, Types, Uses
2023年8月3日 · What is Alternative splicing? Alternative splicing is a natural process where exons of a single precursor mRNA are linked in different arrangements to form two or more different variations of mature mRNAs. This strategy increases the proteome diversity and enables the control of gene expression after transcription.
Alternative splicing as a regulator of development and tissue …
2017年5月10日 · Alternative splicing of eukaryotic transcripts is a mechanism that enables cells to generate vast protein diversity from a limited number of genes. The mechanisms and outcomes...
Mechanisms of alternative splicing regulation: insights from
2009年9月23日 · Alternative splicing is a crucial mechanism for gene regulation and for generating proteomic diversity, which allows individual genes to generate multiple mature mRNA isoforms that can be...
Alternative Splicing Regulatory Networks: Functions, …
Transcripts from nearly all human protein-coding genes undergo one or more forms of alternative splicing, such as inclusion or skipping of individual “cassette” exons, switching between alternative 5′ and 3′ splice sites, differential retention of introns, mutually exclusive splicing of adjacent exons, and other, more complex patterns ...
(PDF) The physiology of alternative splicing - ResearchGate
2022年10月13日 · Alternative splicing is a substantial contributor to the high complexity of transcriptomes of multicellular eukaryotes. In this Review, we discuss the accumulated evidence that most of this...
Researchers discover cell-type-specific link between alternative ...
5 天之前 · Alternative splicing (AS) is a fundamental regulatory mechanism in messenger RNA (mRNA) processing, and abnormal splicing is a major cause of genetic disorders. To understand the genetic ...
Alternative splicing and related RNA binding proteins in human …
2024年2月2日 · Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation, engendering transcript diversity, and modifications in protein structure and functionality....
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