Tendon Pathophysiology - Physiopedia
A reactive tendon is the 1st stage on the tendon continuum and is a non-inflammatory proliferative response in the cell matrix. This is as a result of compressive or tensile overload. The cells change shape and have more cytoplasmic organelles for increased protein production (proteogycans and collagen).
Recent advances in tendinopathy - PMC
According to this, there are three stages to tendon pathology with continuity between them: a) reactive tendinopathy, b) tendon dysrepair (failed healing), and c) degenerative tendinopathy. In the first stage, there is a non-inflammatory proliferative response in the cell and matrix that occurs with acute overload and leads to adaptive ...
Current understanding of the diagnosis and management of …
2022年10月1日 · Reactive tendinopathy is the result of an acute compressive and/or tensile load which provokes a non-inflammatory proliferative cell and matrix response. This situation occurs after an acute overload such as an excessive physical activity periods (Fig. 2).
Treatment of Tendinopathy: What Works, What Does Not, and …
Tendinopathy appears to result from an imbalance between the protective/regenerative changes and the pathologic responses that result from tendon overuse. The net result is tendon degeneration, weakness, tearing, and pain. As the basic science of tendinopathy has evolved, so have the treatment options for these conditions.
Tendinopathy: Update on Pathophysiology - Journal of …
2015年10月31日 · Tendinopathy has become the accepted term to describe a spectrum of changes that occur in damaged and/or diseased tendons. Over the past 2 decades, there have been new insights into tendon pathophysiology of relevance to clinicians, including (1) better characterization of the overuse injury process and the resultant structural and functional ...
reactive changes within the same biopsy, even in very severe, long-standing cases. It is also postulated that there is a resi-dent population of fibroblast-like cells within tendons that, after injury, can differentiate into several lineages (osteo-blast, chondrocyte, adipocyte, tenocyte), leading to metaplasia (eg, bony, carti-
Continuum model of tendon pathology – where are we now?
2013年7月9日 · The model presents clinical, histological and imaging evidence for the progression of tendon pathology as a three-stage continuum: reactive tendinopathy, tendon disrepair and degenerative tendinopathy. It also provides clinical information to assist in identifying the stage of pathology, in addition to proposed treatment approaches for each stage.
Is tendon pathology a continuum? A pathology model to explain …
We propose that there is a continuum of tendon pathology that has three stages: reactive tendinopathy, tendon dysrepair (failed healing) and degenerative tendinopathy (fig 1). The model is described for convenience in three distinct stages; however, as it is a continuum, there is continuity between stages.
(PDF) Tendinopathy - ResearchGate
2021年12月1日 · Tendinopathy describes a complex multifaceted pathology of the tendon, characterized by pain, decline in function and reduced exercise tolerance. The most common overuse...
Tendinopathy - Nature Reviews Disease Primers
2021年1月7日 · Tendinopathy describes a spectrum of changes that occur in damaged and diseased tendons, leading to pain and reduced function. Tendinopathy is characterized by abnormalities in...