Protein kinase domain - Wikipedia
Protein kinases possess a catalytic subunit which transfers the gamma phosphate from nucleoside triphosphates (almost always ATP) to the side chain of an amino acid in a protein, resulting in a conformational and/or dynamic changes affecting protein function.
Protein Kinase Domain - an overview | ScienceDirect Topics
Eukaryote protein kinase domains segregate into two large groups, phosphorylating either serine/threonine or tyrosine residues on target proteins.
Structural features of the protein kinase domain and targeted …
Most protein kinases have other domains that contribute to regulation of kinase activity, oligomerization state, or the recruitment of binding partners. For reasons of space, this review will focus primarily on the kinase domain itself.
蛋白激酶 - 百度百科
蛋白激酶A （Protein kinase A，简称PKA），也称为 环磷酸腺苷依赖蛋白激酶 （cAMP-dependent protein kinase、简称cAPK）。 是一种酶，其活性依赖于细胞中 环磷酸腺苷 （cAMP）的含量。 PKA是一个 全酶 （holoenzyme，由许多次单位组成，是完整的且有作用的酶），它包含了两个调控次单位以及两个代谢次单位。 当细胞中的cAMP较少时，PKA虽然会暂时失去活性，但仍然可以保持结构完整。 当cAMP 浓度增加，cAMP会接上位于两个调控次单位上 …
Protein Kinase C: Structure, Function, and Regulation (*)
The protein kinase C family of enzymes transduces the myriad of signals promoting lipid hydrolysis. The prevalence of this enzyme family in signaling is exemplified by the diverse transduction mechanisms that result in the generation of …
Structural features of the protein kinase domain and targeted …
Here, we review the key regulatory features of the protein kinase family, describe the different types of kinase inhibitors, and highlight examples where the understanding of kinase regulatory mechanisms has gone hand in hand with the development of inhibitors.
The Protein Kinase Family: Conserved Features and Deduced
Phylogenetic mapping of the conserved protein kinase catalytic domains can serve as a useful first step in the functional characterization of these newly identified family members.
Active and Inactive Protein Kinases: Structural Basis for Regulation
1996年4月19日 · Protein kinases exhibit variability in other parts of the kinase domain, and different kinases may contain additional domains, additional subunits, or both. These features allow several different mechanisms for control.
Function, Structure and Topology of Protein Kinases
2020年5月6日 · The dimerization models of kinase activation highlight the importance of protein interactions stabilizing the kinase active state and suggest that also other proteins and domains may act as kinase activators or inhibitors.
A Structurally-Validated Multiple Sequence Alignment of 497 …
2019年12月24日 · We present a parsimonious, structure-based multiple sequence alignment (MSA) of 497 human protein kinase domains excluding atypical kinases.
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