Proopiomelanocortin - Wikipedia
Pro-opiomelanocortin (POMC) is a precursor polypeptide with 241 amino acid residues. POMC is synthesized in corticotrophs of the anterior pituitary from the 267-amino-acid-long polypeptide precursor pre-pro-opiomelanocortin (pre-POMC), by the removal of a 26-amino-acid-long signal peptide sequence during translation. [5] .
Proopiomelanocortin - an overview | ScienceDirect Topics
Proopiomelanocortin (POMC), a pro-hormone, gives rise to numerous active peptides and hormones with a wide range of physiological actions (Toda et al., 2017). In the brain, POMC is expressed in the arcuate nucleus (ARC) of the hypothalamus, …
Role of Proopiomelanocortin-Derived Peptides and Their …
Proopiomelanocortin (POMC) is a multifunctional precursor protein for several biologically active hormones that include ACTH, the MSH (α-, β-, and γ-MSH), and the endogenous opioid β-endorphin (β-ED).
Proopiomelanocortin (POMC): the cutaneous roles of its …
The precursor protein proopiomelanocortin (POMC) produces many biologically active peptides via a series of enzymatic steps in a tissue-specific manner, yielding the melanocyte-stimulating hormones (MSHs), corticotrophin (ACTH) and beta-endorphin.
Proopiomelanocortin - an overview | ScienceDirect Topics
Proopiomelanocortin (POMC) is the 241-amino-acid-long peptide whose posttranslational processing gives rise to several bioactive peptide hormones controlling a large array of different physiologic functions ranging from stress, feeding, and …
Proopiomelanocortin Deficiency Treated with a Melanocortin-4 …
2016年7月21日 · We now present our experience in using a melanocortin-4 receptor agonist, setmelanotide, to treat severe obesity and hyperphagia in two patients with proopiomelanocortin deficiency.
Proopiomelanocortin - an overview | ScienceDirect Topics
Proopiomelanocortin (POMC) is a common precursor of melanocortin (MC), the collective term for adrenocorticotropic hormone (ACTH) and melanophore-stimulating hormone (MSH), and of β-endorphin (β-END).
Unraveling the central proopiomelanocortin neural circuits
2013年2月21日 · Central proopiomelanocortin (POMC) neurons form a potent anorexigenic network, but our understanding of the integration of this hypothalamic circuit throughout the central nervous system (CNS) remains incomplete.
Proopiomelanocortin, a polypeptide precursor with multiple …
Proopiomelanocortin (POMC) is the polypeptide precursor of ACTH. First discovered in anterior pituitary corticotroph cells, it has more recently been revealed to have many other physiological aspects.
Proopiomelanocortin, agouti-related protein, and leptin in …
2015年9月1日 · The hypothalamic melanocortin system plays a critical role in responding to leptin, and disruption of this system at multiple levels causes obesity in humans and animals. This system consists of proopiomelanocortin (POMC) and agouti-related protein (AgRP) neurons and the brain melanocortin receptors (MC-Rs).