PLPP2 Gene - GeneCards | PLPP2 Protein | PLPP2 Antibody
2024年10月2日 · PLPP2 (Phospholipid Phosphatase 2) is a Protein Coding gene. Diseases associated with PLPP2 include Sigmoid Disease and Chronic Recurrent Multifocal Osteomyelitis. Among its related pathways are Sphingolipid metabolism and Metabolism. An important paralog of this gene is PLPP1.
磷脂磷酸酶 2（PLPP2）基因 | MCE - MCE-生物活性分子大师
该基因编码的蛋白质是磷脂酸磷酸酶 (PAP) 家族的成员。 PAP 将磷脂酸转化为甘油二酯，并在甘油脂的从头合成以及磷脂酶 D 介导的受体激活信号转导中发挥作用。 该蛋白质类似于 2A 型磷脂酸磷酸酶 (PPAP2A) 和 2B 型磷脂酸磷酸酶 (PPAP2B) 。 所有三种蛋白质均包含 6 个跨膜区和一个共有 N-糖基化位点。 这种蛋白质已被证明具有膜相关的 PAP 活性。 已经报道了编码不同亚型的三种可变剪接的转录物变体。 [RefSeq 提供，2008 年 7 月] The protein encoded by this gene is a …
Multi-Omic analyses characterize the ceramide/sphingomyelin
2022年10月8日 · The thiol proteinase inhibitor E-64-d ameliorates amyloid-β-induced reduction of sAPPα secretion by reversing ceramide-induced protein kinase C down-regulation in SH-SY5Y neuroblastoma cells ...
Unravelling neuronal and glial differences in ceramide …
2024年11月30日 · We show that human iPSC-derived neurons and glia differ in their rate of ceramide synthesis, ceramide isoform composition, and responses to altered ceramide levels. RNA-sequencing of cells...
Sphingolipid Metabolism as a New Predictive Target Correlated …
2022年3月30日 · PLPP2 encodes for a protein of the phospholipid phosphatase family that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid including sphingosine 1-phosphate/S1P and ceramide 1-phosphate [33,34]. In our work, we observed that the expression of these three genes involved in ceramide synthesis were downregulated in the ...
Expression of PLPP2 in cancer - Summary - The Human Protein Atlas
Expression of PLPP2 (LPP2, PAP-2c, PPAP2C) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.
PLPP2 phospholipid phosphatase 2 [ Homo sapiens (human) ]
2024年9月17日 · PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B).
Transcriptomic landscape based on annotated clinical features …
2023年11月23日 · Immunohistochemistry was performed using tissue microarrays to examine the expression of phospholipid phosphatase 2 (PLPP2) and lipid-raft markers. Lipidomics analysis was used to determine the changes of lipid components in PLPP2-overexpressed cells.
O43688 - UniProt
Magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P (PubMed:16467304, PubMed:9607309, PubMed:9705349).
PLPP2: Potential therapeutic target of breast cancer in PLPP family
2022年11月1日 · As a member of the PLPP family, PLPP2 (phospholipid phosphatase 2) plays a vital role in the occurrence and development of breast cancer, but its mechanism is still unclear. Our research found that PLPP2 was overexpressed in breast cancer, and the higher expression level of PLPP2 showed a worse prognosis for breast cancer patients.