Identification of highly selective covalent inhibitors by phage display
2020年11月16日 · There is currently no rapid, unbiased screening method to identify new classes of covalent inhibitors from highly diverse pools of candidate molecules. Here we describe a phage display method...
Phage display technology and its impact in the discovery of …
2023年11月28日 · Phage display technology is a well-established versatile in vitro display technology that has been used for over 35 years to identify peptides and antibodies for use as reagents and therapeutics, as well as exploring the diversity of alternative scaffolds as another option to conventional therapeutic antibody discovery. Such successes have been ...
Review of phage display: A jack-of-all-trades and master of most ...
2024年1月1日 · Aside from being employed to gain insight to enzyme-substrate interaction that may be responsible for enzyme specificity [210], enzyme phage display can be used to develop and optimise high affinity catalytic site enzyme inhibitors, which could be relevant in therapeutic and drug development areas [211]. For example, a highly potent and ...
Advancement and applications of peptide phage display technology …
2016年1月19日 · Targeting peptides identified using phage display technology may be useful for basic research and translational medicine. In this review article, we summarize the latest technological advancements in the application of phage-displayed peptide libraries to applied biomedical sciences.
Phage display and other peptide display technologies | FEMS ...
2021年10月21日 · Phage display is a molecular technique based on a genetic modification of phage DNA in order to enable the expression of a peptide/protein/antibody fragment on the phage surface by combining them with one of the phage coat proteins (Sioud 2019).
Phage display—A powerful technique for immunotherapy
The phage display technology is a valuable tool in biomedical applications which offers rapid, efficient and relatively inexpensive methods for investigating protein-protein interactions, receptor binding sites, identifying epitopes, mimotopes, functional and accessible sites from antigens.
Phage display for discovery of anticancer antibodies
2024年11月25日 · In this review, we summarize the basics of phage display technology and highlight the advances in anticancer antibody identification and modification via phage display platform. Finally, we describe phage display-derived anticancer monoclonal antibodies that have been approved to date or are in clinical development. 1. Introduction.
Phage display: Concept, innovations, applications and future
2010年11月1日 · The rapid isolation of specific ligands by phage display is advantageous in many applications including selection of inhibitors for the active and allosteric sites of the enzymes, receptor agonists and antagonists, and G-protein binding modulatory peptides.
Covalent inhibitor design using phage display | Nature Methods
2020年11月16日 · A group of researchers led by Matthew Bogyo at the Stanford University School of Medicine has developed a phage display based method to screen for cyclic peptides that can act as irreversible...
Phage Display: An Overview in Context to Drug Discovery - Cell …
2018年12月31日 · Phage display is a powerful tool that allows researchers to identify and isolate peptides with high affinity and specificity for the target of interest.
- 某些结果已被删除