American Physiological Society Journal
American Physiological Society Journal
Physiology and Pathophysiology of Itch | Physiological Reviews
In neuropathic pain, targeting peripheral GABA-R has proven analgesic properties, which could be translated to itch. Central targets of itch act in the central nervous system and include the use of κ-opioid receptor (KOR) agonists and μ-opioid receptor (MOR) antagonists.
Theories of pain: from Specificity to Gate Control
2012年10月3日 · Several theoretical frameworks have been proposed to explain the physiological basis of pain, although none yet completely accounts for all aspects of pain perception. Here, we provide a historical overview of the major contributions, ideas, and competing theories of pain from ancient civilizations to Melzack and Wall's Gate Control Theory of Pain.
under different headings such as nerve injury pain, neural-gia, deafferentation pain, neurogenic pain, and central pain. However, in most instances and now also recognized by IASP, the term neuropathic pain is used to avoid any postu-lated mechanism or a specific anatomical location of the lesion. The history of neuropathic pain reports is ...
Neuropathic Pain: From Mechanisms to Treatment
Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a common chronic pain condition with major impact on quality of life. Examples include trigeminal neuralgia, painful polyneuropathy, postherpetic neuralgia, and central poststroke pain.
Pathobiology of Visceral Pain: Molecular Mechanisms and …
2000年7月1日 · On the basis of comparisons with cerebral activation patterns with somatic pain, the authors of these studies proposed that the ventral cingulate and frontal cortices can be considered the central projections of visceral pain, in contrast to the dorsal cingulate and somatosensory cortices with somatic pain.
Irritable Bowel Syndrome: Methods, Mechanisms, and …
2012年10月1日 · Irritable bowel syndrome (IBS) is one of the most common gastrointestinal ailments among those seeking health care for gastrointestinal disorders. Despite its prevalence, IBS pathophysiology is sti...
It is widely held that such “neuropathic pain” results from nerve injury-triggered pathophysiological changes in both the peripheral and the central nervous systems (PNS, CNS).
Centralization, Central Sensitization and Neuropathic Pain.
2006年8月1日 · But in fact, it frequently yields ongoing paresthesias and pain and an augmented response to applied stimuli. It is widely held that such “neuropathic pain” results from nerve injury-triggered pathophysiological changes in both the peripheral and …
Na+-K+-ATPase, a new class of plasma membrane receptors
2016年4月1日 · Endogenous Digitalis-like Factors as a Key Molecule in the Pathophysiology of Pregnancy-Induced Hypertension and a Potential Therapeutic Target in Preeclampsia