Role of p53 in the Regulation of Cellular Senescence - PubMed
2020年3月8日 · The p53 transcription factor plays a critical role in cellular responses to stress. Its activation in response to DNA damage leads to cell growth arrest, allowing for DNA repair, or directs cellular senescence or apoptosis, thereby maintaining genome integrity. Senescence is a permanent cell-cycle a …
Senescence and aging: the critical roles of p53 | Oncogene - Nature
2013年2月18日 · In this review, we focus on the recent advances on the contribution of p53 to cellular senescence and its implication for cancer therapy, and we will discuss p53’s impact on animal lifespan....
p53 dependence of senescence markers p21v1 and p21v2 in …
2024年10月14日 · We report an inverse relationship between aging and hemorrhagic shock in the expression pattern of p21 v1 and v2 variants. Furthermore, this work, for the first time, provides important...
Ketogenic diet induces p53-dependent cellular senescence in …
2024年5月17日 · The authors concluded that high-fat content, regardless of saturation level, induces cellular senescence in the heart, liver, kidney, and brain, as indicated by increased levels of p53, p21, and senescence-associated β-galactosidase (1).
Senescent cells limit p53 activity via multiple mechanisms to
2022年6月28日 · Here we show, through gene knockdown and analysis of three core biological properties of senescent cells that a relatively large number of senescence-associated super-enhancer-regulated genes...
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence …
Activation of the p53/p21 WAF1/CIP1 and p16 INK4A /pRB tumor suppressor pathways play a central role in regulating senescence. Several other pathways have recently been implicated in mediating senescence and the senescent phenotype.
p53 in senescence - it's a marathon, not a sprint - PubMed
The tumour suppressor p53, a stress-responsive transcription factor, plays a central role in cellular senescence. The role of p53 in senescence-associated stable proliferative arrest has been extensively studied. However, increasing evidence indicates that p53 also modulates the ability of senescent …
Role of p53 in the Regulation of Cellular Senescence - MDPI
2020年3月8日 · This review focuses on the characteristics of senescence and on the recent advances in the contribution of p53 to cellular senescence. Moreover, we also discuss the p53-mediated regulation of several pathophysiological microenvironments that could be associated with senescence and its development.
p53 in senescence – it's a marathon, not a sprint - Sheekey
2021年12月17日 · In this review, we first overview the functional relevance of p53 in senescence focusing on the two major features, stable cell cycle arrest and the senescence-associated secretory phenotype (SASP), and then discuss the unique regulatory mechanism of how p53 and its downstream activities are fine-tuned during senescence.
Senescence regulation by the p53 protein family - PubMed
In this chapter, we provide an overview on how p53, p63, p73, and their isoforms regulate cellular senescence and aging. p53, a guardian of the genome, exerts its tumor suppression activity by regulating a large number of downstream targets involved in cell cycle arrest, DNA repair, apoptosis, and cellular senescence.