Notch signaling pathway - Wikipedia
The mathematical modeling of Notch-Delta signaling thus provides significant insights into lateral inhibition mechanisms and pattern formation in biological systems. It enhances the understanding of cell-cell interaction variations leading to diverse tissue structures, contributing to developmental biology and offering potential therapeutic ...
Do as I say, Not(ch) as I do: Lateral control of cell fate
2019年3月1日 · Notch signaling drives both lateral inhibition and lateral induction patterning. Inhibitive cues prevent cells adopting default states. Inductive cues prompt adoption of specific cell fates. Here, we discuss examples of Notch lateral signaling in flies, worms and mammals.
Enhanced Delta-Notch Lateral Inhibition Model Incorporating ...
2018年6月22日 · We show that lateral inhibition models involving only Delta and Notch proteins can also recapitulate experimental tip-stalk patterns by invoking two mechanisms, specifically, intracellular...
Understanding the Principles of Pattern Formation Driven by Notch ...
We analyze how Notch signaling gives rise to divergent cell fate – lateral inhibition – and convergent cell fate – lateral induction – among neighboring cells.
Lateral inhibition of Notch signaling in neoplastic cells - PMC
During normal development, heterogeneous expression of Notch ligands can result in pathway suppression in the signal-sending cell, a process known as lateral inhibition. It is unclear if an analogous phenomenon occurs in malignant cells.
Modeling the Notch response - PMC - National Center for …
2018年1月1日 · We discuss new modeling approaches to lateral inhibition patterning that take into account cis-interactions between NOTCH receptors and ligands, signaling through long cellular protrusions, cell division processes, and coupling to external signals.
Notch Signaling: The Core Pathway and Its ... - Cell Press
A model termed “lateral inhibition” explains how Notch signaling is coupled to a transcriptional feedback mechanism, leading to different cell-fate outcomes for the initially equivalent cells.
Delivering the Lateral Inhibition Punchline: It’s All About ... - AAAS
2010年10月26日 · New ways to understand lateral inhibition in patterning sensory bristles in the fruit fly are proposed. Experimental and theoretical biologists have long been fascinated with the emergence of self-organizing patterns in developing organisms, and much attention has focused on Notch-mediated lateral inhibition.
Synthetic lateral inhibition governs cell-type bifurcation
2015年2月5日 · Lateral inhibition controlled by Delta–Notch signalling is the core mechanism for the choice of alternative cell types by homogeneous neighbouring cells. Here, we show that cells engineered...
Dynamic Notch signaling in neural progenitor cells and a
2008年10月28日 · Notch-mediated lateral inhibition operates reciprocally between neural progenitors before neuronal formation and then from neurons to neural progenitors after neuronal formation, but in either...
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