Neurogranin: A Potential Biomarker of Neurological and …
2020年10月6日 · Neurogranin (Ng) is a small protein usually expressed in granule-like structures in pyramidal cells of the hippocampus and cortex. However, its clinical value is not fully clear so far.
Neurogranin: A Potential Biomarker of Neurological and Mental …
Neurogranin (Ng) is a small protein usually expressed in granule-like structures in pyramidal cells of the hippocampus and cortex. However, its clinical value is not fully clear so far. Currently, Ng is proved to be involved in synaptic plasticity, ...
Neurogranin - an overview | ScienceDirect Topics
Neurogranin (Ng) is a neural-specific postsynaptic protein that is highly enriched in dendrites, is regulated by synaptic activity, and promotes synaptogenesis (Garrido-Garcia et al., 2019).
Neurogranin, a synaptic protein, is associated with memory …
Neurogranin is a neural-specific postsynaptic protein involved in LTP signaling. 4 – 6 Concentrated on dendritic spines in the hippocampus and basal forebrain, neurogranin binds to calmodulin to regulate calcium influxes. 7 In animals, neurogranin knockdown models inhibit LTP and cognition, 8 while upregulation promotes LTP and improves ...
Neurogranin as a Reliable Biomarker for Synaptic Dysfunction in ...
Neurogranin is a calmodulin-binding protein discovered in 1990, but only in recent years it gained attention as a potential biomarker of neurodegeneration . The term “neurogranin” refers to its expression in granule-like structures within excitatory neurons of …
NRGN Gene - GeneCards | NEUG Protein | NEUG Antibody
2024年10月2日 · Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns.
Neurogranin as a cognitive biomarker in cerebrospinal fluid …
2020年4月29日 · In recent years, clinical studies have reported that the level of cerebrospinal fluid (CSF) and blood neurogranin (Ng) are closely related to the occurrence and subsequent progression of AD.
Molecular forms of neurogranin in cerebrospinal fluid - PMC
2020年12月17日 · Neurogranin (Ng) is a 78 amino acid neuronal protein and a biomarker candidate for Alzheimer's disease (AD). Ng has been suggested to bind to calmodulin and phosphatidic acid via its centrally located IQ domain.
Neurogranin as a Reliable Biomarker for Synaptic Dysfunction in ...
2021年12月12日 · (1) Background: Neurogranin is a post-synaptic protein expressed in the neurons of the hippocampus and cerebral cortex. It has been recently proposed as a promising biomarker of synaptic dysfunction, especially in Alzheimer's disease (AD).
Diagnostic and Prognostic Utility of the Synaptic Marker Neurogranin …
Neurogranin is a postsynaptic neuronal protein that has demonstrated utility as a cerebrospinal fluid (CSF) marker of synaptic loss in AD. Objective To investigate the diagnostic and prognostic utility of CSF neurogranin levels in a large, well-characterized cohort of individuals with symptomatic AD and cognitively normal controls.
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