Fluorescent probes for monitoring myeloperoxidase-derived …
2022年6月3日 · In this study, we have compared three classes of fluorescent probes for monitoring myeloperoxidase-derived hypochlorous acid, including boronate-, aminophenyl- and thiol-based fluorogenic...
Environment-sensitive turn-on fluorescent probe enables live cell ...
2024年11月12日 · Myeloperoxidase (MPO) plays an important role in the immune response of human neutrophils and has been implicated in autoimmune conditions, cardiovascular disorders, and neurodegeneration....
Hypochloric acid fluorescence probe targeting MPO for cell imaging
2023年10月2日 · Abstract. Objective：The current study aims to synthesize hypochloric acid（HClO）fluorescent probes targeting myeloperoxidase （MPO）and evaluate its HClO tracing activity.Methods：Si-rhodamine was used as the fluorophore to synthesize SiRho-GABA-KYC.The UV spectrum，fluorescence spectrum，and pH stability and selectivity were detected with UV spectrophotometer and fluorescence ...
Fluorescent molecular probes for imaging and detection of …
2023年2月1日 · Myeloperoxidase (MPO) is a heme-containing enzyme that is mainly released by activated neutrophils, and catalyzes the production of hypochlorous acid (HClO) from H 2 O 2 and Cl-[54], [55], [56]. Excess HClO is a strong oxidant that oxidizes DNA, proteins and lipids, leading to cellular dysfunction and tissue damage.
A New and Fast-Response Fluorescent Probe for Monitoring …
2023年8月14日 · Myeloperoxidase (MPO) is an essential member of the heme peroxidase superfamily. This enzyme catalyzes the production of hypohalous acids (HOCl, hypochlorous acid; HOBr, hypobromous acid; HOI, hypoiodous acid) and also hypothiocyanous acid (HOSCN) from hydrogen peroxide (H 2 O 2 ) and the respective halide ions (Cl − , Br − , I − ), as ...
A HClO-specific near-infrared fluorescent probe for …
2016年12月15日 · In this study, a turn-on near infrared (NIR) fluorescent probe Cy7-NphS has been designed and developed for highly selective and sensitive sensing of HClO and Myeloperoxidase (MPO) with fast response time. The newly developed probe has been successfully applied in real-time monitoring of HClO and MPO activity in …
A Fluorescent Probe for the Detection of Myeloperoxidase …
2007年11月26日 · The myeloperoxidase (MPO)-derived oxidant hypochlorous acid (HOCl/OCl −) is implicated in the pathogenesis of atherosclerosis and other inflammatory states. We have synthesized an imaging probe, sulfonaphthoaminophenyl fluorescein (SNAPF), that selectively reacts with HOCl.
A fluorescent probe for the detection of myeloperoxidase
The myeloperoxidase (MPO)-derived oxidant hypochlorous acid (HOCl/OCl(-)) is implicated in the pathogenesis of atherosclerosis and other inflammatory states. We have synthesized an imaging probe, sulfonaphthoaminophenyl fluorescein (SNAPF), that selectively reacts with HOCl. SNAPF detects HOCl produ …
A HClO-specific near-infrared fluorescent probe for …
2016年12月15日 · Findings identify myeloperoxidase as a component of human vascular lesions and suggest that this heme protein can generate reactive species that damage lipids and proteins may contribute to atherogenesis by catalyzing oxidative reactions in the vascular wall.
A New and Fast-Response Fluorescent Probe for Monitoring
2023年8月14日 · In this report, imaging of HOCl was realized with a thiomorpholine-based probe as derivative of nitrobenzothiadiazole (NBD-S-TM). The fluorescence is based on photoinduced electron transfer by using nitrobenzothiadiazole core …