24.2: DNA Mutations, Damage, and Repair - Biology LibreTexts
In nature, mutagenesis, or the process of generating DNA mutations, can lead to changes that are harmful, beneficial, or have no effect. Harmful mutations can lead to cancer and various heritable diseases, but beneficial mutations are the driving force of evolution.
Mechanisms of DNA damage, repair and mutagenesis - PMC
A variety of DNA damaging agents can induce DNA damage, which becomes substrate for specific DNA repair pathways. Upper panel shows representative DNA damaging agents: errors from replication, spontaneous base deamination, alkylating agents, toxins, oxidative agents, ionizing radiation, UV radiation, crosslinking agents, aromatic compounds and ...
DNA damage repair: historical perspectives, mechanistic pathways and ...
2021年7月9日 · In this review, we first illustrate the timeline steps for the understanding the roles of DNA damage repair in the promotion of cancer and cancer therapy developed, then we summarize the...
DNA Damage and DNA Repair: Types and Mechanism - Microbe …
2023年9月8日 · To overcome the harmful effects of DNA damage, cells have various systems such as DNA repair mechanisms, damage tolerance pathways, cell cycle checkpoints, and cell death pathways. These systems work together to repair or tolerate DNA damage, ensuring the overall survival and functionality of cells.
Mutational signatures are jointly shaped by DNA damage and repair
2020年5月1日 · Cells possess an armamentarium of DNA repair pathways to counter DNA damage and prevent mutation. Here we use C. elegans whole genome sequencing to systematically quantify the contributions...
Genetics, DNA Damage and Repair - StatPearls - NCBI Bookshelf
2023年8月14日 · A point mutation is typically a change in just one base pair in a DNA molecule, and a difference of even only one nucleotide can be enough to cause significant problems in the body. For example, sickle cell disease is a genetic disorder that results because of a difference in a single nucleotide in the DNA of a carrier when compared to the DNA ...
The genomics of oxidative DNA damage, repair, and
2020年1月1日 · Recent technological advancements and novel data analysis strategies have revealed that oxidative DNA damage, its repair, and related mutations distribute heterogeneously over the genome at multiple levels of resolution. The involved mechanisms act in the context of genome sequence, in interaction with genome function and chromatin.
(PDF) DNA damage and mutation. Types of DNA damage
2014年2月23日 · This review outlines the basic types of DNA damage caused by exogenous and endogenous factors, analyses the possible consequences of each type of damage and discusses the need for different...
Strand-resolved mutagenicity of DNA damage and repair | Nature
2024年6月12日 · At multiple scales, we show DNA damage-induced mutations are largely shaped by the influence of DNA accessibility on repair efficiency, rather than gradients of DNA damage. Finally, we...
Exploring DNA Damage and Repair Mechanisms: A Review with …
2024年1月24日 · DNA damage is a critical factor contributing to genetic alterations, directly affecting human health, including developing diseases such as cancer and age-related disorders. DNA repair mechanisms play a pivotal role in safeguarding genetic integrity and preventing the onset of these ailments.