Muscle-to-Brain Signaling Via Myokines and Myometabolites
Although most studies have focused on changes in the expression of myokines in muscle, the modulation of myokine secretion is a less-explored mechanism that may also contribute to modulate muscle-to-brain signaling in response to exercise as well as inactivity.
Role of Myokines in Regulating Skeletal Muscle Mass and Function
The myokine-mediated signaling pathways lead to its target genes expression, which in turn regulate muscle cell proliferation, differentiation, and growth. It ultimately increases/decreases muscle mass.
Myokine - Wikipedia
A myokine is one of several hundred cytokines or other small proteins (~5–20 kDa) and proteoglycan peptides that are produced and released by skeletal muscle cells (muscle fibers) in response to muscular contractions. [1]
The muscle-enriched myokine Musclin impairs beige fat ... - Nature
2023年7月19日 · Here, the authors report the myokine Musclin as a negative regulator of beige adipose thermogenesis and systemic energy homeostasis through Tfr1/PKA signalling mediated muscle fat crosstalk.
Biological Aspects of Selected Myokines in Skeletal Muscle: Focus …
In the last decade, clear evidence has emerged that the cellular components of skeletal muscle are important sites for the release of proteins and peptides called “myokines”, suggesting that skeletal muscle plays the role of a secretory organ. After ...
Muscle–Organ Crosstalk: The Emerging Roles of Myokines
2020年5月11日 · Recent advances show that skeletal muscle produces myokines in response to exercise, which allow for crosstalk between the muscle and other organs, including brain, adipose tissue, bone, liver, gut, pancreas, vascular bed, and …
FNDC1 is a myokine that promotes myogenesis and muscle …
2024年11月20日 · This study identifies the fibronectin domain-containing protein FNDC1 as a myokine that promotes myogenesis and muscle regeneration with potential therapeutic use for treating muscle injuries and related disorders.
Myokines in skeletal muscle physiology and metabolism: Recent ... - PubMed
Myokines are molecules produced and secreted by skeletal muscle to act in an auto-, para- and endocrine manner to alter physiological function of target tissues.
Myokines: The endocrine coupling of skeletal muscle and bone
Myokines exert an autocrine function in regulating muscle metabolism as well as a paracrine/endocrine regulatory function on distant organs and tissues, such as bone, adipose tissue, brain and liver.
Role of Myokines in Regulating Skeletal Muscle Mass and Function
2019年1月30日 · Maintenance of skeletal muscle mass is considered an essential determinant of muscle strength and function. Myokines are cytokines synthesized and released by myocytes during muscular contractions.
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