Mr. Oligo Emmanuel — Soroti University
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Mre11-Rad50 oligomerization promotes DNA double-strand break …
2022年5月2日 · We demonstrate that Mre11-Rad50-Xrs2 oligomerization facilitates foci formation, DNA damage signaling, repair, and telomere maintenance in vivo. Mre11-Rad50 oligomerization does not affect its...
A new recombineering system for precise genome-editing in
2019年1月10日 · Developing this high efficiency method for DNA uptake in S. oneidensis has enabled us to introduce single-stranded DNA oligonucleotides (oligos) to perform in vivo homologous...
We demonstrate that short-range DNA end resection is driven by MR oligomerization mediated by MR head domain interactions, which stabilize MR on DNA and enhance its endonuclease activity at...
Large-Scale de novo Oligonucleotide Synthesis for Whole …
2021年6月22日 · De novo oligonucleotide synthesis (oligo synthesis) is the synthesis of defined sequences of single-strand nucleic acids. Its early efforts could be found out in the 1950s, followed by large-scale automation in the 1980s ( Kosuri and Church, 2014 ).
【科研干货】一文读懂Oligo合成 - 分析测试百科网
2023年8月2日 · 寡核苷酸(Oligonucleotide)是一类多个相邻核苷酸残基以磷酸二酯键连接的短链核苷酸的总称，包括DNA或RNA，其人工化学合成过程是一个多步连续的反应[1]。
Mre11-Rad50 oligomerization promotes DNA double-strand break …
2022年5月2日 · Combining pathway reconstitution in electron microscopy, biochemical assays and genetic studies, we show that S. cerevisiae Mre11-Rad50 with or without Xrs2 forms higher-order assemblies in...
Optimized design of antisense oligomers for targeted rRNA …
2021年1月1日 · We introduce a novel Web tool, Oligo-ASST, that simplifies oligo design to target regions with optimal thermodynamic properties, and additionally can generate compact, common oligo pools that simultaneously target divergent RNAs, e.g. across different species.
第一期 Oligo的化学合成 - Takara
Oligo即寡核苷酸链，在生物学各领域中应用非常广泛，我们常用的测序引物、PCR & qPCR的引物探针、NGS捕获探针、FISH探针等都属于Oligo范畴。 根据功能不同，可以在Oligo上修饰荧光基团、淬灭基团和化学基团（如，氨基、巯基等）等。
大规模Oligo合成 - 生工生物
采用AKTA OligoPilot 100/AKTA OligoProcess等先进设备，可合成从克到千克级高纯度DNA/RNA Oligos，包括符合医药研发所用的小核酸原料（ASO、siRNA、miRNA、saRNA和Aptamer等)、用于疫苗生产的免疫佐剂CpG-ODN、用于mRNA纯化的填料Oligo(dT)、以及DEL引物、Trimer引物和CRISPR sgRNA。