Morphine metabolites - PubMed
In man, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) are the major metabolites of morphine. The metabolism of morphine occurs not only in the liver, but may also take place in the brain and the kidneys. The glucuronides are mainly eliminated via bile and urine.
Opioid Metabolites - Journal of Pain and Symptom Management
With morphine, the active metabolite morphine-6-glucuronide exerts important clinical opioid effects when it accumulates in the plasma of patients with renal failure. However, after short-term administration of morphine, its contribution to the central …
Opioid Metabolism - Mayo Clinic Proceedings
Morphine may also undergo minor routes of metabolism, including N-demethylation to normorphine or normorphine 6-glucuronide, diglucuronidation to morphine-3, 6-diglucuronide, and formation of morphine ethereal sulfate.
Morphine-3-Glucuronide, Physiology and Behavior - PMC
Morphine metabolism involves mainly hepatic glucuronidation by uridine 5′-diphospho-glucuronosyltransferase (UGT) phase II enzymes. Glucuronidation occurs at the C3-OH and C6-OH positions, leading to two active metabolites: morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) (Lotsch, 2005).
Hydrocodone, Oxycodone, and Morphine Metabolism and …
The major metabolic pathway for morphine is via glucuronidation by UGT2B7 to form its major metabolite, morphine-3-glucuronide, and its minor metabolite, morphine-6-glucuronide (Coffman et al., 1997, 1998; Donnelly et al., 2002; Stone et al., 2003; Ohno et al., 2008).
Pharmacology of morphine metabolites | Current Pain and
The major metabolic pathway of morphine includes formation of glucuronides of morphine: morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) in the liver, as well as the formation of minor morphine metabolites (normorphine, codeine, and morphine-3-sulfate).
Relationships Among Morphine Metabolism, Pain and Side …
2003年1月1日 · The two metabolites of morphine, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G), have been studied intensively in animals and humans during the past 30 years in order to elucidate their precise action and possible contribution to the desired effects and side effects seen after morphine administration.
With morphine, the active metabolite morphine-6-glucuronide exerts important clinical opioid effects when it accumulates in the plasma of patients with renal failure. However, after short-term administration of morphine, its contribution to the central …
Morphine metabolism, transport and brain disposition
2011年12月24日 · Morphine is primarily metabolized in the liver by uridine-5′-diphosphate (UDP) glucoronosyltransferase, with specific affinity for the UGT2B7 isoenzyme. This isoenzyme is responsible for the formation of both glucuronide species, but at different amounts (5 times more M3G than M6G).
Morphine Pharmacokinetics and Metabolism in Humans
2012年11月4日 · A major finding was a slowly declining terminal phase of morphine and metabolites that was evident both in plasma and in urinary excretion versus time curves, where the half-lives of morphine, M3G and M6G were 15.1 ± 6.5h, 11.2 ± …
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