Lipid Metabolism in Regulation of Macrophage Functions - Cell …
Oct 6, 2020 · In this review, we describe different aspects of how cellular lipid metabolism influences macrophage biology. More specifically, we discuss how lipids provide an important energy source, and serve as essential components of cell membranes and as signaling molecules to modulate various macrophage functions.
Reprogramming cholesterol metabolism in macrophages and its …
Jan 11, 2022 · Macrophages rapidly reprogram their metabolic state to facilitate inflammation, resolution, and effector functions [4, 5]. The metabolic reprogramming of macrophages targets nearly all aspects of...
Metabolism of tissue macrophages in homeostasis and pathology …
Dec 7, 2021 · In short, tissue fuels (such as glucose, lipids or amino acids) are converted into metabolites (such as pyruvate, tricarboxylic acid [TCA] cycle intermediates, fatty acids or free cholesterol) by...
Current Understanding on the Role of Lipids in Macrophages and ...
This review discusses the significance of lipids in adipose tissue macrophages, tumor-associated macrophages, microglia and peritoneal macrophages. Accumulation of macrophages with impaired lipid metabolism is often characteristically observed in several metabolic disorders. Stress signals differentially regulate lipid metabolism.
Impact of Lipid Metabolism on Macrophage Polarization
Jul 27, 2023 · This review focuses on lipid metabolism and macrophage functions and addresses potential molecular targets for the treatment of macrophage-related diseases. While lipogenesis is crucial for lipid accumulation and phagocytosis in M1 macrophages, M2 macrophages likely rely on fatty acid β-oxidation to utilize fatty acids as their primary energy ...
Macrophages and lipid metabolism - PMC - PubMed Central …
As it is now appreciated that cell metabolism not only provides energy but also greatly influences the phenotype and function of the cell, here we review how lipid metabolism affects macrophage phenotype and function and the specific roles played by macrophages in the pathogenesis of lipid-related diseases.
Lipid Metabolism in Regulation of Macrophage Functions
Dec 1, 2020 · In this review, we describe different aspects of how cellular lipid metabolism influences macrophage biology. More specifically, we discuss how lipids provide an important energy source, and serve as essential components of cell membranes and as signaling molecules to modulate various macrophage functions.
Protumoral lipid droplet–loaded macrophages are enriched in …
Oct 30, 2024 · Here, we characterized tumor-associated foam cells (TAFs), a type of lipid droplet–loaded macrophage, ... Glioblastoma presents a formidable clinical challenge because of its complex microenvironment. ... J. Yan, T. Horng, Lipid metabolism in regulation of macrophage functions. Trends Cell Biol. 30, 979–989 (2020). Crossref. PubMed. Web of ...
Impact of Lipid Metabolism on Macrophage Polarization ... - MDPI
Jun 28, 2023 · Lipids and their metabolites are players in intricate signaling pathways that modulate macrophages’ responses to pathogens, phagocytosis, ferroptosis, and inflammation. This review focuses on lipid metabolism and macrophage functions and addresses potential molecular targets for the treatment of macrophage-related diseases.
Lipid Metabolism in Regulation of Macrophage Functions
Here, we review how macrophage lipid metabolism can be dynamically altered in different physiological and pathophysiological contexts and the key regulators involved. We also describe how alterations in lipid metabolism are integrated with the signaling pathways that specify macrophage functions, allowing for coordinated control of macrophage ...