Myc - Wikipedia
Myc proteins are transcription factors that activate expression of many pro-proliferative genes through binding enhancer box sequences (E-boxes) and recruiting histone acetyltransferases (HATs).
An Overview of MYC and Its Interactome - PMC - PubMed Central …
We present a view of MYC as a sensor that integrates multiple cellular signals to mediate a broad transcriptional response controlling many aspects of cell behavior. We also describe the larger transcriptional network linked to MYC with emphasis on the MXD family of MYC antagonists.
MYC Gene - GeneCards | MYC Protein | MYC Antibody
2024年12月25日 · MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphoma and High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit. Among its related pathways are Prolactin Signaling and Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
MYC on the Path to Cancer - PMC - PubMed Central (PMC)
The MYC oncogene contributes to the genesis of many human cancers. Recent insights into its expression and function have led to new cancer therapeutic opportunities. MYC’s activation by bromodomain proteins could be inhibited by drug-like molecules, ...
The MYC oncogene — the grand orchestrator of cancer growth …
The MYC proto-oncogenes encode a family of transcription factors that are among the most commonly activated oncoproteins in human neoplasias. Indeed, MYC aberrations or upregulation of MYC-related pathways by alternate mechanisms occur in the vast ...
The MYC oncogene — the grand orchestrator of cancer growth …
2021年9月10日 · The MYC proto-oncogenes are among the most commonly activated proteins in human cancer, yet the clinical efficacy of MYC-targeted agents remains to be demonstrated.
MYC protein interactors in gene transcription and cancer
2021年6月29日 · In this Perspective, we highlight how multiple proteins that interact with MYC enable MYC to regulate several central control points of gene transcription. These include promoter binding,...
MYC: a multipurpose oncogene with prognostic and therapeutic ...
2021年8月9日 · MYC (mostly referred to as c-Myc) is a super-transcription factor encoded by the MYC gene located at chromosome 8 q24.21 [1]. The MYC oncoproteins (C-myc, N-myc, and L-myc) controls the transcription of nearly 15% of expressed genes [2].
MYC as a target for cancer treatment - ScienceDirect
2021年3月1日 · The aim of this article is to critically review these developments and discuss the current status of MYC inhibitors for cancer treatment. First, however, we briefly review the structure of the MYC protein, its mode of action and its deregulation in malignancy.
Targeting Myc Interacting Proteins as a Winding Path in Cancer …
2021年9月29日 · This review, we concentrate on a number of Myc interacting proteins that contribute to Myc function (Figure 1), and also discussed current inhibitors and strategies targeting the interacting proteins, in the interest of providing new opportunities for Myc-related cancer treatment.