Crystal structure of listeriolysin O reveals molecular details of ...
2014年4月22日 · Listeriolysin O (LLO) is an essential virulence factor of Listeria monocytogenes that causes listeriosis.
Listeria monocytogenes: towards a complete picture of its …
2017年11月27日 · Listeria monocytogenes is a food-borne pathogen responsible for a disease called listeriosis, which is potentially lethal in immunocompromised individuals.
Listeriolysin O: a phagosome-specific cytolysin revisited
Listeriolysin O (LLO) is an essential determinant of Listeria monocytogenes pathogenesis that mediates the escape of L. monocytogenes from host cell vacuoles, thereby allowing replication in the cytosol without causing appreciable cell death.
The molecular mechanisms of listeriolysin O-induced lipid membrane ...
2021年7月1日 · Listeria monocytogenes is an intracellular food-borne pathogen that causes listeriosis, a severe and potentially life-threatening disease. Listeria uses a number of virulence factors to proliferate and spread to various cells and tissues.
Listeriolysin O: a key protein of Listeria monocytogenes with …
2006年7月1日 · This review provides an updated overview on the importance of listeriolysin O (LLO) in the pathogenicity of L. monocytogenes, focusing mainly on two aspects: (1) the structure–function relationship of LLO and (2) its role in intra- and extracellular signalling.
Relative Roles of Listeriolysin O, InlA, and InlB in Listeria ...
2018年9月21日 · L. monocytogenes virulence factors include two surface invasins, InlA and InlB, known to promote bacterial uptake by host cells, and the secreted pore-forming toxin listeriolysin O (LLO), which disrupts the phagosome to allow bacterial proliferation in the cytosol.
Listeriolysin O: the Swiss army knife of Listeria - ScienceDirect
2012年8月1日 · Listeriolysin O (LLO) is a toxin produced by Listeria monocytogenes, an opportunistic bacterial pathogen responsible for the disease listeriosis. This disease starts with the ingestion of contaminated foods and mainly affects immunocompromised individuals, newborns, and pregnant women.
Listeria monocytogenes - an overview | ScienceDirect Topics
Of the 13 serotypes described for L. monocytogenes, serotypes 1/2a, 1/2 b, and 1/2c are mostly isolated from food and food processing environments with serotype 1/2a being most prevalent.
The Production of Listeriolysin O and Subsequent Intracellular ...
2020年3月30日 · Listeria monocytogenes is a foodborne pathogen capable of secreting listeriolysin O (LLO), a pore-forming toxin encoded by the hly gene. While the functions of LLO have been studied extensively, how the production of LLO is modulated by the intestinal environment, devoid of oxygen and …
The Listeriolysin O PEST-like Sequence Co-opts AP-2-Mediated ...
2018年6月13日 · Listeriolysin O (LLO) is a cholesterol-dependent cytolysin that mediates escape of Listeria monocytogenes from a phagosome, enabling growth of the bacteria in the host cell cytosol. LLO contains a PEST-like sequence that prevents it from killing infected cells, but the mechanism involved is unknown.