Lactate metabolism in human health and disease - Nature
2022年9月1日 · Lactic acid production and clearance. The production of lactate as fuel increases when the demand for oxygen and ATP exceeds the cellular supply, such as during strenuous exercise and infection...
Modern Perspective of Lactate Metabolism - PMC
Lactate metabolism is ubiquitous and plays a role in energy supply, glycemia maintenance, cerebral metabolism, and signaling, with implications for various clinical conditions, such as glucose control, traumatic brain injury (TBI), heart failure, and inflammation [5–7,11,12].
Lactate: the ugly duckling of energy metabolism - Nature
2020年7月20日 · By providing mammalian cells with both a convenient source and sink for three-carbon compounds, circulating lactate enables the uncoupling of carbohydrate-driven mitochondrial energy generation...
Lactate as a fulcrum of metabolism - PMC - PubMed Central (PMC)
By shuttling between producer (driver) and consumer (recipient) cells lactate fulfills at least three purposes: 1] a major energy source for mitochondrial respiration; 2] the major gluconeogenic precursor; and 3] a signaling molecule.
Lactate metabolism in human health and disease - PubMed
2022年9月2日 · The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism, as identified by studies on the Warburg effect. The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging signaling molecule that coordinates s …
Comprehensive review on lactate metabolism in human health
Metabolic pathways involved in lactate metabolism are important to understand the physiological response to exercise and the pathogenesis of prevalent diseases such as diabetes and cancer. Monocarboxylate transporters are being investigated as potential targets for diagnosis and therapy of these and …
Comprehensive review on lactate metabolism in human health
2014年7月1日 · In this review we summarize current information concerning several aspects of lactate metabolism and its implications in human health, including the metabolic routes implicated in lactate homeostasis, the handling of lactate by different human tissues, the monocarboxylate transporters involved in lactate movement across cell membranes, the ...
Lactic Acid: What Is It, What Increases It, and More - Osmosis
2022年10月12日 · Lactic acid, also called lactate, is a product of pyruvate metabolism under anaerobic conditions. The tissues that produce most lactic acid are the muscle cells and red blood cells. An elevated lactate level and a pH equal to or less than 7.35 cause lactic acidosis.
Lactate physiology in health and disease - Oxford Academic
2006年6月1日 · Lactate concentrations >5 mmol litre −1 with severe metabolic acidosis predicts high mortality. Impaired lactate clearance, rather than hypoxic tissue production of lactate, is the cause of hyperlactaemia in stable septic patients. The normal plasma lactate concentration is 0.3–1.3 mmol litre −1.
The Science and Translation of Lactate Shuttle Theory
2018年4月3日 · Once thought to be a waste product of anaerobic metabolism, lactate is now known to form continuously under aerobic conditions. Shuttling between producer and consumer cells fulfills at least three purposes for lactate: (1) a major energy source, (2) the major gluconeogenic precursor, and (3) a sign …