Recognition of lipopolysaccharide pattern by TLR4 complexes
2013年12月6日 · Overview of LPS recognition by TLR4–MD-2. LPS binding induces dimerization of the TLR4–MD-2 complex, which is proposed to enable dimerization of the intracellular TIR domains and...
TLR4 and CD14 trafficking and its influence on LPS-induced pro ...
In this review, we focus on the mechanisms of the internalization and intracellular trafficking of TLR4 and CD14, and also of LPS, in immune cells and discuss how dysregulation of the endo-lysosomal compartment contributes to the development of diverse human diseases.
The structural basis of lipopolysaccharide recognition by the TLR4…
2009年3月1日 · Toll-like receptor (TLR) 4 and myeloid differentiation factor 2 (MD-2) form a heterodimer that recognizes a common ‘pattern’ in structurally diverse LPS molecules. To understand the...
LPS/TLR4 signal transduction pathway - PubMed
The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. LPS/TLR4 signaling has been intensively studied in the past few years.
The Role of Toll-Like Receptor 4 in Infectious and Noninfectious ...
Toll-like receptor 4 (TLR4) belongs to the family of pattern recognition receptors (PRRs). They are highly conserved receptors that recognize conserved pathogen-associated molecular patterns (PAMPs), thus representing the first line of defense against infections.
Lipopolysaccharide Recognition in the Crossroads of TLR4 and …
In response to bacterial infection, the TLR4/MD-2 complex that is expressed on the surface of macrophages, monocytes, dendritic, and epithelial cells senses picomolar concentrations of endotoxic LPS and triggers the production of various pro-inflammatory mediators.
Deletion of TLR4 attenuates lipopolysaccharide-induced acute liver ...
2021年1月25日 · In this study, we investigated the role of TLR4 in LPS-induced acute liver injury (ALI) in mice with a focus on inflammation and apoptosis. Wild-type (WT) and TLR4-knockout (TLR4 −/−) mice were...
TLR4 and CD14 trafficking and its influence on LPS-induced pro ...
2020年10月15日 · In this review, we focus on the mechanisms of the internalization and intracellular trafficking of TLR4 and CD14, and also of LPS, in immune cells and discuss how dysregulation of the endo-lysosomal compartment contributes to the development of diverse human diseases.
LPS/TLR4 signal transduction pathway - ScienceDirect
2008年5月1日 · The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. LPS/TLR4 signaling has been intensively studied in the past few years.
Lipopolysaccharide (LPS)-binding protein stimulates CD14 …
Toll-like receptor 4 (TLR4) is an indispensable immune receptor for lipopolysaccharide (LPS), a major component of the Gram-negative bacterial cell wall. Following LPS stimulation, TLR4 transmits the signal from the cell surface and becomes internalized in an endosome.