Maximilian F. Konig - Google Scholar
A critical reappraisal of neutrophil extracellular traps and NETosis mimics based on differential requirements for protein citrullination MF Konig, F Andrade Frontiers in immunology 7, 461 ,...
A Critical Reappraisal of Neutrophil Extracellular Traps and NETosis ...
2016年11月4日 · We delineate two distinct biological processes, leukotoxic hypercitrullination (LTH) and defective mitophagy, which have been erroneously classified as "NETosis." While these NETosis mimics share morphological similarities with NETosis (i.e., extracellular DNA release), they are biologically distinct.
Microbiome in rheumatoid arthritis - The Laboratory of Maximilian Konig ...
We showed that periodontal disease was characterized by the presence of citrullinated autoantigens in gingival crevicular fluid and identified the bacterial pore-forming toxin leukotoxin A (LtxA) as the unique mechanism by which Aa triggers protein arginine deiminase (PAD) activity and abnormal citrullination.
A Critical Reappraisal of Neutrophil Extracellular Traps and …
2016年11月4日 · In this review, we examine the evidence for PAD4 activation during NETosis and provide experimental data to suggest that protein citrullination is not a universal feature of NETs. We delineate two...
A Critical Reappraisal of Neutrophil Extracellular Traps and NETosis ...
2016年11月4日 · Mitochondrial DNA (mtDNA) expulsion, the result of a constitutive defect in mitophagy, represents a second NETosis mimic. In the presence of interferon-α and immune complexes, this process can generate highly interferogenic oxidized mtDNA, which has previously been mistaken for NETosis in SLE.
Insight into Neutrophil Extracellular Traps through Systematic ...
2019年3月12日 · Konig M. F., Andrade F. A critical reappraisal of neutrophil extracellular traps and NETosis mimics based on differential requirements for protein citrullination. Frontiers in Immunology .
Neutrophil Extracellular Traps in Atherosclerosis and …
2017年2月17日 · Konig MF, Andrade F. A critical reappraisal of neutrophil extracellular traps and netosis mimics based on differential requirements for protein citrullination. Front Immunol . 2016; 7 :461. doi: 10.3389/fimmu.2016.00461.
A critical reappraisal of neutrop... preview & related info - Mendeley
(2016) Konig, Andrade. Frontiers in Immunology. NETosis, an antimicrobial form of neutrophil cell death, is considered a primary source of citrullinated autoantigens in rheumatoid arthritis (RA) and immunogenic DNA in systemic lupus erythematosus (SLE).
Antigen-specific immunotherapy - Konig Lab at Johns Hopkins
Our goal is to develop personalized and antigen-specific immunotherapies that can achieve that, using orthogonal novel technologies and engineering platforms developed in our lab. Chimeric antigen receptor (CAR)-T cell therapies targeting B cells have revolutionized the treatment of blood cancers over the past decade and can be curative.
Chat with Konig | character.ai | Personalized AI for every moment …
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