A comprehensive comparative study on LSD1 in different cancers …
2022年10月5日 · HOXA-AS2 directly binds with LSD1 and EZH2, and the ternary complex thus formed represses the transcriptional activity of tumor suppressor genes p21 and KLF2. …
Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 …
LSD1-dependent demethylation regulates activity of non-histone proteins. Effects of LSD1-mediated demethylation of non-histone proteins p53-E2F1 and PPP1R12A (a), HIF-1α (b), …
Upregulated long non-coding RNA AGAP2-AS1 represses LATS2 and KLF2 ...
2016年5月19日 · The results showed that EZH2 and LSD1 could directly bind to LATS2 and KLF2 promoter region and mediate H3K27 trimethylation or H3K4me2 demethylation modification .
Demethylase-independent roles of LSD1 in regulating enhancers …
2023年8月22日 · Here, we dissect the role of LSD1 and its demethylase activity in gene regulation and cell fate transition. Surprisingly, the catalytic inactivation of LSD1 has a mild impact on …
Long noncoding RNA HOXA-AS2 represses P21 and KLF2 …
2017年1月23日 · The mechanistic investigations showed that HOXA-AS2 could interact with EZH2 (enhancer of zeste homolog 2), LSD1 (lysine specific demethylase 1) and recruit them …
Long non-coding RNA DLEU1 predicts poor prognosis of gastric
2017年12月27日 · Mechanistic investigation demonstrated that the function mediated by DLEU1 in GC cells was depended on LSD1-mediated KLF2 transcription suppression. It was notarized …
The Role of LSD1 and LSD2 in Cancers of the Gastrointestinal …
Lysine-specific demethylase 1 (LSD1) and its homolog, lysine-specific demethylase 2 (LSD2), are overexpressed in a variety of human cancer types and, thus, regulate tumour progression.
The histone demethylase lysine-specific demethylase-1–mediated ...
2017年4月5日 · Mechanistic investigation was performed to document by which mechanism LSD1 regulates its underlying target KLF2 in GC cells. Our findings highlight that LSD1 critically …
Upregulated long non-coding RNA AGAP2-AS1 represses LATS2 and KLF2 ...
2016年5月19日 · The results showed that EZH2 and LSD1 could directly bind to LATS2 and KLF2 promoter region and mediate H3K27 trimethylation or H3K4me2 demethylation modification …
The multifaceted role of post-translational modifications of LSD1 …
2024年4月15日 · LSD1 (lysine-specific demethylase 1) is the first identified histone demethylase that can remove monomethylation or dimethylation modifications from histone H3 lysine K4 …