STAT3 and HIF1α cooperatively mediate the transcriptional and ...
2023年7月5日 · Under pathological conditions, the crosstalk between JAK/STAT3 and hypoxia/HIF1α pathways is significant: rheumatoid arthritis is an autoimmune disease characterized by high levels of inflammation...
30岁了！ CELL重磅综述：JAK-STAT通路全面解读！ - 健康界
2022年11月14日 · Janus 激酶 (JAK)-信号转导和转录激活因子 (STAT) 通路的发现源于对细胞如何响应干扰素 (IFN)的研究，提供了一种细胞信号转导的范例。 美国国立卫生研究院 (NIH)的 John J. O’Shea 及其团队是解析JAKs和STATs家族通路在免疫调节中作用的领先者，他们综述的JAK-STAT通路研究文章于2022年10月发表在 CELL 期刊上， 概述了JAK-STAT通路的主要里程碑式事件，并讨论了目前的重大挑战和未来机遇。 作者 | Ting. 01 背景介绍. Janus 激酶 (JAK) 信号 …
JAK1 inactivation promotes proliferation and migration of …
2022年11月14日 · JAK1 overexpression downregulates transcription of HIF target genes under hypoxia. These findings provide novel insights into the functional link between JAK1 LOF mutations and abnormal HIF pathway activation in EC and suggest that pharmacological inhibition of HIF1/2 represents a promising therapeutic strategy targeting JAK1-mutated ECs.
Secretion-mediated STAT3 activation promotes self-renewal of …
2017年11月20日 · Increased HIF-1α activates the JAK1/2-STAT3 axis and enhances tumor stem-like cell self-renewal. Our data further demonstrate the importance of Vascular Endothelial Growth Factor (VEGF)...
The JAK/STAT signaling pathway: from bench to clinic
2021年11月26日 · In liver fibrosis, JAK1 is a constitutive TGFβRI-binding protein; thus, STAT3 is activated directly through JAK1 within minutes of TGFβ stimulation in a SMAD-independent manner.
MicroRNAs and JAK/STAT3 signaling: A new promising
2022年7月1日 · Hypoxia-inducible factor 1 (HIF1) is an important transcription factor in response to hypoxic conditions containing two subunits including, an alpha subunit (HIF-1a, oxygen-sensitive subunit) and a beta subunit (HIF-1b). 170, 171 It also has a role in cancer biologics such as tumor growth, metastasis, and angiogenesis. 172 Consistent with the ...
The interplay between HIF-1α and long noncoding GAS5 regulates the JAK1 ...
Long non-coding RNA (lncRNA) GAS5 is associated with hypoxia-induced diseases whereas hypoxia-inducible factor-1α (HIF-1α) plays an important role in hypoxic injury of cells. The current study explores the regulatory functions of GAS5/HIF-1α which co-play in anoxic injury among rat cardiomyocytes H9C2 cells.
Pro-survival Phenotype of HIF-1α: Neuroprotection Through
2023年10月17日 · HIF-1 is a heterodimeric protein complex that plays a significant role in responding to low concentrations of oxygen or hypoxia and is constitutively expressed as a subunit-β and an oxygen-dependent subunit-α. During normoxic conditions, HIF-1α is synthesized and degraded by the ubiquitin-proteasome system [2].
Overexpression of HIF-1α protects PC12 cells against OGD/R …
2020年4月8日 · HIF-1α overexpression attenuated OGD/R-evoked injury in PC12 cells and remarkably reversed OGD/R-triggered inhibitory effects on ERK1/2 and JAK1/STAT3 pathways. Besides, miR-134 was also down-regulated by HIF-1α overexpression in PC12 cells.
Implication of Hypoxia-Inducible Factor-1 (HIF-1) As a New …
2018年11月29日 · Inhibition of HIF-1, binding to hypoxia response elements (HRE), by low doses of echinomycin (1 nM), significantly impaired proliferation and survival. Using an Annexin-V/7-AAD flow cytometry assay apoptosis was found to be selectively induced in JAK2V617F positive, but not JAK2WT cells after echinomycin treatment.