Islet Encapsulation: New Developments for the Treatment of …
This article focuses on islet encapsulation, either by co-encapsulation or modification of the encapsulated material, in order to reduce the attack of the immune system on the graft and to maintain the cellular activity and physiological function as much as possible.
Advances in islet encapsulation technologies - Nature
2016年12月23日 · Here, Desai and Shea discuss the emerging potential of islet cell encapsulation including new strategies, assess key challenges facing the human translation of this technology and highlight ...
Islet Encapsulation: Physiological Possibilities and Limitations
2017年6月15日 · These in vitro experiments highlight the importance of the dead space of the capsules and call for approaches involving conformal islet encapsulation, in which the immunoprotective barrier is created directly on the surface of the islets to be transplanted.
Encapsulated islet transplantation | Nature Reviews Bioengineering
2024年9月24日 · In this Review, we highlight different islet-encapsulation designs, examining how these can be optimized to improve material biocompatibility, oxygen supply and revascularization at transplant...
Islet cell encapsulation – Application in diabetes treatment
Following a short overview of the different approaches to islet encapsulation, we provide a summary of the merits and demerits of each approach of the encapsulation technology.
Advances in islet encapsulation technologies - PMC
The choice and design of encapsulation materials can enhance engraftment and promote islet survival post-transplantation. In contrast to unencapsulated islets 44, encapsulated islets are typically delivered extrahepatically, with transplantation sites that include the intraperitoneal cavity, subcutaneous space and the omentum 45-48. A challenge ...
Islet Encapsulation: New Developments for the Treatment of …
2022年4月14日 · Encapsulation into semipermeable biomaterials provides a strategy that allows nutrients, oxygen and secreted hormones to diffuse through the membrane while blocking immune cells and the like out of the capsule, allowing long-term graft survival and avoiding long-term use of immunosuppression.
Encapsulated Islet Transplantation: Strategies and Clinical Trials
2024年12月3日 · Islet encapsulation allows the protection of this tissue without the use of toxic medications, while also expanding the donor pool to include animal sources. Before the widespread application of this therapy, there are still issues that need to be resolved.
To enable islet transplantation and restore autonomous glucose monitoring and insulin secretion, islets or β cells can be encapsulated in immuno-protective, polymeric micro- or macroscale...
treatments, islet encapsulation presents the possibility of increasing the availability of donor cells by making xeno-grafts and other cellular transplants possible. Although there are several viable cell sources for islet encapsulation, human islet cells are an ideal choice for is-let transplants. Recently, the first successful living-donor