Mechanisms of type-I- and type-II-interferon-mediated signalling …
2005年5月1日 · There are two main classes of interferon (IFN): type I IFNs and type II IFN. There are many type I IFNs, including IFN-α, IFN-β and IFN-ω, and all of these bind a common cell-surface...
Interferon - StatPearls - NCBI Bookshelf - National Center for ...
2023年7月10日 · This activity outlines the different types of interferons, namely interferon alpha, beta, and gamma. It discusses the pharmacological properties of different interferons, their medical uses, methods of administration, potential adverse effects, and other properties.
What Are Interferons (IFNs)? - Cleveland Clinic
There are three main types of interferons: Interferon-alpha (or alfa). Interferon-beta. Interferon-gamma. Interferons are broadly classified into three main types (alpha, beta and gamma) based on their cellular source and inducing agents. More recently, interferon lambda has been discovered and is under investigation.
γ-干扰素 - 维基百科，自由的百科全书
干扰素-γ可以与 干扰素伽玛受体 （ 英语 ： Interferon-gamma receptor ） (IFNGR)结合，进而调节JAK-STAT通路。 干扰素-γ激活 抗原提呈细胞 ，通过上调 转录因子 T-bet而促进I型辅助T细胞(Th1细胞)的分化。
Interferon - Wikipedia
Interferon beta (IFN-β) can be produced by all nucleated cells when they recognize that a virus has invaded them. The most prolific producers of IFN-α and IFN-β are plasmacytoid dendritic cells circulating in the blood. Monocytes and macrophages can also produce large amounts of type I interferons when stimulated by viral molecular patterns.
The Type I Interferons: Basic Concepts and Clinical Relevance in …
In this review, we cover some general aspects of type I interferon genes, with emphasis on interferon-alpha, and various aspects of molecular mechanisms triggered by type I interferons and toll-like receptor signaling by the Janus activated kinase/signal transducer activation of transcription (JAK-STAT) pathway and interferon regulatory factor ...
The Role of Structure in the Biology of Interferon Signaling
2020年11月11日 · Interferons (IFNs) are a family of cytokines with the unique ability to induce cell intrinsic programs that enhance resistance to viral infection. Induction of an antiviral state at the cell, tissue, organ, and organismal level is performed by three distinct IFN families, designated as Type-I, Type-II, and Type-III IFNs.
[Interferon-alpha, beta, gamma] - PubMed
There are three types of interferons (IFN), alpha, beta and gamma. IFN-alpha is produced in the leukocytes infected with virus, while IFN-beta is from fibroblasts infected with virus. IFN-gamma is induced by the stimulation of sensitized lymphocytes …
干扰素 - 维基百科，自由的百科全书
干扰素（ interferon ，IFN [1] ）是一组具有抗病毒活性、抗肿瘤、免疫调节、维持细胞自身稳定等多种生物学活性功能的糖蛋白 [2] 。干扰素最初发现的功能是可干扰多种病毒的复制，因而得名。
干扰素信号通路 (Interferon signaling pathway) - Abcam中文官网
IFN（干扰素）是抵御病毒感染的第一道防线中的强效细胞因子和关键组分 1，主要通过直接诱导可抑制病毒复制的抗病原体分子对抗措施实现炎症和免疫控制 2。 参与抗病毒感染的 IFN 有三种类型（I 型、II 型和 III 型）。 I 型和 III 型 IFN 由免疫和组织特异性细胞表达，对病毒感染做出响应，两者共享重要抗病毒特性 2,3。 在经典通路中，I 型和 II 型 IFN 与其各自的受体 IFNAR1/2 和 IFNR1/IL10R2 相互作用，诱导构象变化，从而活化与受体相关的 JAK（Janus 激酶）家 …