Inflammasome - Wikipedia
Inflammasomes are cytosolic multiprotein complexes of the innate immune system responsible for the activation of inflammatory responses and cell death. [1][2] They are formed as a result of specific cytosolic pattern recognition receptors (PRRs) sensing microbe-derived pathogen-associated molecular patterns (PAMPs), damage-associated molecular p...
A comprehensive guide to studying inflammasome activation …
2020年9月7日 · Here, we describe a comprehensive protocol that details several in vitro (in bone marrow–derived macrophages) and in vivo (in mice) strategies for activating the inflammasome and explain how to...
The Inflammasomes - Cell Press
2010年3月19日 · Strong associations between dysregulated inflammasome activity and human heritable and acquired inflammatory diseases highlight the importance this pathway in tailoring immune responses. Here, we comprehensively review mechanisms directing normal inflammasome function and its dysregulation in disease.
The role of inflammasomes in human diseases and their potential …
2024年1月5日 · In this article, we provide a summary of the biological and pathological roles of inflammasomes in health and disease. We also highlight key evidence that suggests targeting inflammasomes could be...
Inflammasomes: mechanism of action, role in disease, and
2015年6月29日 · The inflammasomes are innate immune system receptors and sensors that regulate the activation of caspase-1 and induce inflammation in response to infectious microbes and molecules derived from host...
A comprehensive guide for studying inflammasome activation …
Our workflow assesses inflammasome activation via the formation of the ASC speck, cleavage of caspase-1 and gasdermin D, release of IL-1β, IL-18, caspase-1, and lactate dehydrogenase from the cell, and real-time analysis of cell death by imaging. Analyses take up to approximately 24 hours to complete.
A 360° view of the inflammasome: Mechanisms of activation, cell …
2023年5月25日 · Inflammasomes are critical initiators of inflammation and adaptive immunity with far-reaching effects on human health and disease. This review provides a 360° view of the mechanisms of inflammasome formation, subcellular regulation, and …
Inflammasome: structure, biological functions, and therapeutic …
Inflammasome is a protein complex that plays an important role in innate immunity and body's response to attacks from both pathogens and endogenous dangers signals. Inflammasome as a whole is composed of three functional components, …
Regulatory Mechanisms of the NLRP3 Inflammasome, a Novel …
2019年7月10日 · The nod-like receptor family pyrin domain containing 3 (NLRP3) is currently the most widely studied inflammasome and has become a hot topic of recent research. As a macromolecular complex, the NLRP3 inflammasome is activated to produce downstream factors, including caspase-1, IL-1β, and IL-18, which …
Mechanisms and Functions of Inflammasomes - Cell Press
2014年5月22日 · Here, we review recent progress in our understanding of inflammasome signaling, the consequences of aberrant inflammasome signaling in human disease, and the therapeutic potential of inflammasome modulation in inflammatory diseases.