Indolyl Group - an overview | ScienceDirect Topics
An indolyl group is defined as a 1-ethyl-indolyl group linked at the 5-position on a pyrimidine backbone, which is crucial for antiproliferative activity in the context of chemistry. AI generated definition based on: Bioorganic & Medicinal Chemistry, 2022
Indolyl Definition & Meaning | Merriam-Webster Medical
The meaning of INDOLYL is any of seven isomeric monovalent radicals C8H6N derived from indole by removal of one hydrogen atom.
Biomedical Importance of Indoles - PMC
Indole (1, Figure 1) is the parent substance of a large number of important compounds that occur in nature. Indole and the simple alkylindoles are colourless crystalline solids with a range of odours from naphthalene-like in the case of indole itself to faecal in the case of skatole (3-methylindole, 2) (Figure 1).
Indoles - Chemistry Online
2024年4月22日 · Indole is a volatile crystalline solid with a melting point of 52 ºC and a persistent odor. Its properties are those of an aromatic compound. Much of the chemistry of indole is analogous to that of pyrrole. For example, it is weakly basic and the stable cation is formed by protonation of carbon.
Bisindolyl Maleimides and Indolylmaleimide Derivatives—A Review …
Bisindolylmaleimides (BIMs) are widely recognised for their activity against protein kinases and from a synthetic perspective can be highly functionalised or chemically manipulated. This provides the opportunity to generate novel analogues and derivatives with unique biological profiles.
Indolylboronic Acids: Preparation and Applications - PMC
Indole is one of the simplest fused heterocyclic compounds known to act as a key scaffold of many naturally occurring molecules. For example, skatole (F1-1), melatonin (F1-2), serotonin (F1-3), and tryptamine (F1-4) are all well-known indole-based compounds (Figure 1).
An efficient synthesis of 3-indolyl-3-hydroxy oxindoles and 3,3-di ...
2015年1月1日 · Sulfonated-β-cyclodextrin (β-CD-SO 3 H) promoted efficient and fast electrophilic substitution reaction of indoles with various isatins reflux in water is reported affording various 3-indolyl-3-hydroxy oxindoles and 3,3-di(indolyl)indolin …
Indolyl-Ynones: Building Blocks for Molecular Diversity
2024年1月11日 · This review centers on the synthetic strategies employed with indolyl-ynones. Indolyl-ynone, owing to its highly reactive ynone moiety, frequently partakes in dearomatizing spirocyclization reactions and subsequent rearrangement reactions when subjected to various reaction conditions.
indolyl group (CHEBI:51609) - EMBL-EBI
indolyl group: ChEBI ID CHEBI:51609: Definition A group derived from indole by removal of a hydrogen atom from a ring atom. Stars This entity has been manually annotated by the ChEBI Team.
Synthesis of Indolyl Isothiocyanate and Its Inhibitory ... - PubMed
2024年10月2日 · In summary, this study provided fundamental reference data for the derivative synthesis of these indolyl isothiocyanate compounds. Keywords: fungicidal activity; indolyl isothiocyanate; substructure splicing; theoretical calculation.
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