IgG Subclasses and Allotypes: From Structure to Effector Functions
The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ in their constant region, particularly in their hinges and upper CH2 domains. These regions are involved in binding to both IgG-Fc receptors (FcγR) and C1q.
The unique properties of IgG4 and its roles in health and disease
2023年4月24日 · IgG4 is the least abundant subclass of IgG in human serum and has unique functional features. IgG4 is largely unable to activate antibody-dependent immune effector responses and, furthermore,...
Immunoglobulin G - Wikipedia
There are four IgG subclasses (IgG1, 2, 3, and 4) in humans, named in order of their abundance in serum (IgG1 being the most abundant). [12]
Human IgG4: a structural perspective - PMC - PubMed Central …
IgG4 plays a protective role in allergy by acting as a blocking antibody, and inhibiting mast cell degranulation, but a deleterious role in malignant melanoma, by impeding IgG1-mediated anti-tumor immunity. These findings highlight the importance of understanding the interaction between IgG4 and Fcγ receptors.
Immunoglobulin G (IgG)- Structure, Subclasses and Functions
2022年6月24日 · There are four IgG subclasses (IgG1, 2, 3, and 4) in humans, named in order of their abundance in serum (IgG1 being the most abundant). Subclasses IgG1, IgG2, IgG3, and IgG4 are differentiated on the basis of the size of the hinge region, position of interchain disulfide bonds, and molecular weight.
IgG1 has the largest relative contribution to total IgG, followed by IgG2 then IgG3 and IgG4. Although IgG4 is the least abun-dant IgG subclass overall, specific responses can be dominated by...
The Biology of IgG Subclasses and Their Clinical Relevance to ...
Immunoglobulin G (IgG) is the dominant immunoglobulin and can be divided into 4 distinct subclasses. The evolution of IgG subclass switches is regulated by interaction with T cells and follows a 1-way direction (IgG3 → IgG1 → IgG2 → IgG4).
Sequence variants influencing the regulation of serum IgG …
2024年9月14日 · Immunoglobulin G (IgG) is the main isotype of antibody in human blood. IgG consists of four subclasses (IgG1 to IgG4), encoded by separate constant region genes within the Ig heavy chain locus...
Immunoglobulin G (IgG) – Properties, Structure and Functions
2024年1月23日 · There are four subclasses of IgG: IgG1, IgG2, IgG3, and IgG4 which are differentiated on the position of interchain disulfide bonds, basis of the size of the hinge region and molecular weight along with differences based …
Is it bad, is it good, or is IgG4 just misunderstood?
2023年2月7日 · IgG4 antibodies constitute a relatively small proportion of total anti-spike IgG after vaccination, will also likely be of higher affinity because they emerge late, and can form mixed immune complexes with IgG1; in practical terms, they are unlikely to compromise immunity in vaccinated patients at this time.