Hydrogen peroxide: a metabolic by-product or a common …
Recent findings, however, demonstrate that one specific ROS, hydrogen peroxide (H 2 O 2), is produced by mitochondria through a specialized enzyme to control cellular growth and death.
Regulation of Metabolic Processes by Hydrogen Peroxide Generated …
Nov 9, 2020 · Hydrogen peroxide (H 2 O 2) is an important oxidizing molecule that regulates the metabolisms of aerobic organisms. Redox signaling comprises physiological oxidative stress (eustress), while excessive oxidative stress causes damage to molecules.
Peroxisomal Hydrogen Peroxide Metabolism and Signaling in …
Hydrogen peroxide (H2O2), a non-radical reactive oxygen species generated during many (patho)physiological conditions, is currently universally recognized as an important mediator of redox-regulated processes.
Peroxisome quality control and dysregulated lipid metabolism in ...
Sep 11, 2020 · Peroxisomes play vital roles in biological processes including the metabolism of lipids and reactive oxygen species, and the synthesis of key molecules, including bile acid and cholesterol.
Hydrogen peroxide: a metabolic by-product or a common …
We propose that genes that control H2O2 production are selected determinants of lifespan. The reactive oxygen species that are generated by mitochondrial respiration, including hydrogen peroxide (H2O2), are potent inducers of oxidative damage and mediators of ageing.
Peroxisomal Hydrogen Peroxide Metabolism and Signaling in …
Jul 26, 2019 · We first briefly introduce the basic concepts of how H 2 O 2 can drive cellular signaling events. Next, we outline the peroxisomal enzyme systems involved in H 2 O 2 metabolism in mammals and reflect on how this oxidant …
The Role of Hydrogen Peroxide in Redox-Dependent Signaling: …
Hydrogen peroxide (H2O2) is an important metabolite involved in most of the redox metabolism reactions and processes of the cells. H2O2 is recognized as one of the main molecules in the sensing, modulation and signaling of redox metabolism, and it ...
Role of Metabolic H2O2 Generation - Journal of Biological Chemistry
Hydrogen peroxide, the nonradical 2-electron reduction product of oxygen, is a normal aerobic metabolite occurring at about 10 nm intracellular concentration. In liver, it is produced at 50 nmol/min/g of tissue, which is about 2% of total oxygen uptake at steady state.
Peroxisomal hydrogen peroxide signaling: A new chapter in …
Feb 1, 2024 · Hydrogen peroxide (H 2 O 2), a natural metabolite commonly found in aerobic organisms, plays a crucial role in numerous cellular signaling processes. One of the key organelles involved in the cell's metabolism of H 2 O 2 is the peroxisome.
hydrogen peroxide metabolic process Gene Ontology Term …
Nov 19, 2024 · The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA. …
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