Histone methylation - Wikipedia
Histone methylation is a process by which methyl groups are transferred to amino acids of histone proteins that make up nucleosomes, which the DNA double helix wraps around to form chromosomes. Methylation of histones can either increase or decrease transcription of genes, depending on which amino acids in the histones are methylated, and how ...
Writing, erasing and reading histone lysine methylations
2017年4月28日 · This review summarizes enzymes responsible for histone lysine methylation and demethylation and how histone lysine methylation contributes to various biological processes.
组蛋白甲基化修饰（Histone Lysine Methylation） - 知乎专栏
组蛋白甲基化（Histone methylation）是真核生物染色体上包裹DNA的组蛋白之离胺酸或精胺酸被甲基化的转译后修饰，多发生在组蛋白H3与组蛋白H4向外延伸的N端尾，此反应由组蛋白甲基转移酶（HMT）催化，将S-腺苷甲硫…
Histone lysine methyltransferases in biology and disease
2019年10月3日 · Methylation of lysines on histone and non-histone proteins is generated by protein lysine methyltransferases (KMTs; referred to as ‘writers’) and removed by protein lysine demethylases...
Histone lysine methylation dynamics: establishment, regulation, and ...
2012年11月30日 · Histone lysine methylation has emerged as a critical player in the regulation of gene expression, cell cycle, genome stability, and nuclear architecture. Over the past decade, a tremendous amount of progress has led to the characterization of methyl modifications and the lysine methyltransferases (K …
The diverse functions of histone lysine methylation - Nature
2005年11月1日 · Histone methylation occurs on arginine and lysine residues and is catalysed by enzymes belonging to three distinct families of proteins — the PRMT1 family, the SET-DOMAIN -containing...
Histone methylation: a dynamic mark in health, disease and …
The discovery of a histone H3 lysine 4 (H3K4) demethylase, LSD1 (Lysine Specific Demethylase 1, also known as KDM1A), revealed that histone methylation is in fact reversible 11. Now, a plethora of methyltransferases and demethylases have been identified that mediate the addition and removal of methyl groups from different lysine residues on ...
The Role of DNA Methylation and Histone Modifications in ...
Histone methylation is performed on the residues lysine and arginine by histone methyltransferase (HMT) enzymes. Lysines can be mono-, di-, and trimethylated while arginines can be mono- and symmetrically or asymmetrically dimethylated.
The diverse functions of histone lysine methylation - PubMed
Covalent modifications of histone tails have fundamental roles in chromatin structure and function. One such modification, lysine methylation, has important functions in many biological processes that include heterochromatin formation, X-chromosome inactivation and transcriptional regulation.
Lysine Methylation Regulators Moonlighting outside the Epigenome
2019年9月19日 · Lysine methylation is a key regulator of histone and non-histone protein function, cellular processes, and disease progression. Cornett et al. discuss recent progress in understanding molecular functions associated with lysine methylation signaling and highlight the need for continued study of this dynamic and widespread posttranslational ...
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