Hyper IgE Syndrome (Job's Syndrome) | Symptoms & Treatment
Hyper IgE syndrome is an immune deficiency caused by a genetic mutation. It can cause serious skin and lung infections. Read about symptoms, issues and treatment.
Hyper IgE syndrome | Immune Deficiency Foundation - Primary …
Hyper IgE syndromes (HIES) are rare forms of primary immunodeficiencies (PI) characterized by recurrent eczema, skin abscesses, lung infections, eosinophilia (high numbers of eosinophils in the blood), and high serum levels of immunoglobulin E (IgE).
Hyper-Immunoglobulin E Syndromes (HIES)
Many different syndromes are known to lead to high levels of an antibody called immunoglobulin E, or IgE. Many more such syndromes likely remain unknown. Collectively, these conditions are called hyper-IgE syndromes, or HIES. Other conditions, such as severe eczema, can lead to extremely high IgE levels that are not caused by a syndrome at all.
Hyperimmunoglobulin E syndrome - Wikipedia
Elevated IgE is the hallmark of HIES. An IgE level greater than 2,000 IU/mL is often considered diagnostic. [17] However, patients younger than 6 months of age may have very low to non-detectable IgE levels.
Job Syndrome - StatPearls - NCBI Bookshelf
2023年8月28日 · Job Syndrome (Hyper-IgE syndrome) is a rare, primary immunodeficiency distinguished by the clinical triad of atopic dermatitis, recurrent skin staphylococcal infections, and recurrent pulmonary infections. The disease is characterized by elevated IgE levels with an early onset in primary childhood.
Hyper-IgE Syndrome - Hyper-IgE Syndrome - The Merck Manuals
2023年10月17日 · Hyper-IgE syndrome is a hereditary combined B-cell and T-cell immunodeficiency characterized by recurrent staphylococcal abscesses of the skin, sinopulmonary infections, and severe pruritic eosinophilic dermatitis. Diagnosis is confirmed by measurement of serum IgE levels.
The Hyper IgE Syndromes - PMC - PubMed Central (PMC)
The hyper IgE syndromes (HIES) are rare primary immune deficiencies characterized by elevated serum IgE, rash and recurrent bacterial infections of the skin and lung. Autosomal dominant HIES, the most common disease in this group, results from STAT3 mutations and has a variety of connective tissue and skeletal abnormalities.
Hyper-IgE syndrome: a case report - PMC - PubMed Central (PMC)
Hyper-IgE syndrome (HIES), also known as Job syndrome, is a rare primary immunodeficiency disorder characterized by elevated serum IgE levels, recurrent infections, and various clinical features. Early diagnosis, prompt management of infections, and ...
Hyper-IgE Syndrome - Hyper-IgE Syndrome - The Merck Manuals
Hyper-IgE syndrome is a hereditary immunodeficiency disorder characterized by recurring skin abscesses, sinus and lung infections, and a severe rash that appear during infancy. Levels of immunoglobulin E (IgE) are very high. In infants with hyper-IgE syndrome, abscesses form in the skin, joints, lungs, or other organs.
STAT3 Hyper IgE Syndrome - GeneReviews® - NCBI Bookshelf
2010年2月23日 · STAT3 hyper IgE syndrome (STAT3 -HIES) is a primary immune deficiency syndrome characterized by elevated serum IgE, eczema, and recurrent skin and respiratory tract infections, together with several nonimmune features.