Hepcidin - Wikipedia
Hepcidin is a protein that in humans is encoded by the HAMP gene. Hepcidin is a key regulator of the entry of iron into the circulation in mammals. [6] During conditions in which the hepcidin level is abnormally high, such as inflammation, serum iron falls due to iron trapping within macrophages and liver cells and
Hepcidin: Definition, Function & Tests - Cleveland Clinic
2022年7月28日 · Hepcidin plays an essential role in regulating how your body uses iron. By preventing iron export, hepcidin controls your body’s ability to make hemoglobin and red blood cells. In doing so, hepcidin plays an indirect role in determining the availability of oxygen throughout your entire body.
Physiology, Hepcidin - StatPearls - NCBI Bookshelf
2023年4月17日 · Hepcidin is a peptide hormone produced in the liver that plays a crucial role in iron homeostasis. Iron is an essential part of oxygen transport within the body and is present in hemoglobin, myoglobin, and the electron transport chain.
Role of hepcidin in the pathophysiology and diagnosis of anemia
Hepcidin production is suppressed in the case of iron deficiency; the feedback loop between iron and hepcidin should ensure the appropriate physiological concentration of iron in the plasma. Hepcidin production is also regulated by the erythropoietic process, whose core activity is characterized by high iron consumption.
Hepcidin: what every gastroenterologist should know - Gut
The circulating peptide hepcidin is important in the normal response to iron overload, the pathogenesis of haemochromatosis, and possibly the anaemia of chronic disease In health, the body content of iron is maintained within fairly narrow limits to provide sufficient iron for synthesis of ferroproteins essential for oxygen transport and ...
Hepcidin in the diagnosis of iron disorders | Blood | American …
2016年6月9日 · Hepcidin, a liver-derived peptide hormone, is a key regulator of systemic iron homeostasis, and its unbalanced production contributes to the pathogenesis of a spectrum of iron disorders.
Hepcidin - the Iron Regulatory Hormone - PMC - PubMed Central …
Hepcidin is now acknowledged to be the main iron regulatory hormone. It is a 25-amino acid peptide exclusively synthesized by the liver, initially identified as part of a search for novel antimicrobial peptides. 1 There was no indication that it had an additional role in iron metabolism until 2001, when mouse studies were published showing that ...
Hepcidin - PubMed
Hepcidin is an iron-regulating peptide hormone made in the liver. It controls the delivery of iron to blood plasma from intestinal cells absorbing iron, from erythrocyte-recycling macrophages, and from iron-storing hepatocytes.
Iron metabolism and iron disorders revisited in the hepcidin era
This review emphasizes the most recent findings in iron biology, deregulation of the hepcidin-ferroportin axis in iron disorders and how research results have an impact on clinical disorders. Insufficient hepcidin production is central to iron overload while …
Hepcidin Signaling in Health and Disease: Ironing Out the Details
Hepcidin, a peptide hormone produced by hepatocytes, is the central regulator of systemic iron homeostasis through its interaction with ferroportin, the major cellular iron export protein. Hepcidin binding to ferroportin results in reduced iron export from macrophages and intestinal absorptive cells, leading to decreased serum iron levels.
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