HDACs, histone deacetylation and gene transcription: from
2007年2月27日 · Histone deacetylases (HDACs) and histone acetyl transferases (HATs) are two counteracting enzyme families whose enzymatic activity controls the acetylation state of …
Repression of telomerase gene promoter requires human-specific …
The human telomerase reverse transcriptase (hTERT) gene is repressed in most somatic cells, whereas the expression of the mouse mTert gene is widely detected. To understand the …
Histone deacetylases and cancer: causes and therapies
2001年12月1日 · HDAC inhibitors are proving to be an exciting therapeutic approach to cancer, but how do they exert this effect? Together, histone acetyltransferases and histone …
Telomerase activation by histone deacetylase inhibitor in normal …
2001年7月7日 · The present findings clearly demonstrated that one of the HDAC inhibitors, TSA, activates telomerase through transcriptional activation of hTERT promoter in normal renal cells …
Roles for Histone Acetylation in Regulation of Telomere ... - PubMed
We thought to test the effects of histone acetylation levels on telomere length using histone deacetylase (HDAC) inhibitor (sodium butyrate, NaB) that mediates histone hyperacetylation …
Roles of histone deacetylases in epigenetic regulation: emerging ...
2012年3月12日 · The zinc-dependent mammalian histone deacetylase (HDAC) family comprises 11 enzymes, which have specific and critical functions in development and tissue …
Histone deacetylase modulators provided by Mother Nature
2012年2月12日 · Histone deacetylase inhibitors (HDACi) are epigenetically active drugs that induce the hyperacetylation of lysine residues within histone and non-histone proteins, thus …
Histone Deacetylases (HDACs): Evolution, Specificity, Role in
2020年5月15日 · Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with …
HDAC9 regulates the alternative lengthening of telomere …
2016年12月2日 · The histone deacetylase (HDAC) family plays significant roles in various cellular processes. In addition to the regulation of gene expression, HDACs are also known to directly …
Histone deacetylase inhibitor AR42 regulates telomerase activity …
2013年5月24日 · In this study, the effect of a novel HDAC inhibitor, AR42, on telomerase activity in a PTEN-null U87MG glioma cell line was evaluated. Our results demonstrated that AR42 …