The gastric HK-ATPase: structure, function, and inhibition
In this review, the structure and function of the H,K-ATPase and inhibitors of this enzyme will be discussed. The gastric H,K-ATPase is found in the parietal cell of the stomach and a small …
A structural overview of the plasma membrane Na+,K+-ATPase and H+ ...
2010年12月22日 · Crystal structures and functional studies of the Na +,K + -ATPase and the H + -ATPase have provided insight into their mechanisms of action in eukaryotic cells. Plasma …
Proton-Potassium (H (+)/K (+)) ATPases: Properties and Roles ... - PubMed
Most recently, several K (+)-competitive inhibitors of the ATPase are being developed. Here, we introduce gastric H (+)/K (+)-ATPase and its related proteins for gastric acid secretion, and …
The renal H+-K+-ATPases: physiology, regulation, and structure
These reports and recent studies in mice lacking both HKalpha (1) and HKalpha (2) suggest important roles for the renal H (+)-K (+)-ATPases in acid/base balance as well as potassium …
Acid secretion and the H,K ATPase of stomach. - PubMed Central …
These independent pathways converge to activate the gastric acid pump, the H+,K+ ATPase. Activation is a function of the association of the ATPase with a potassium chloride transport …
Role of potassium in acid secretion - PMC - PubMed Central …
Potassium (K +) ions are critical for the activation and catalytic cycle of the gastric H +,K + -ATPase, resulting in the secretion of hydrochloric acid into the parietal cell canaliculus.
Crystal structures of the gastric proton pump | Nature
2018年4月4日 · Here we present crystal structures of the H+, K+-ATPase in complex with two blockers, vonoprazan and SCH28080, in the luminal-open state, at 2.8 Å resolution.
The renal H+-K+-ATPases: physiology, regulation, and structure ...
2010年1月1日 · The H+-K+-ATPases are ion pumps that use the energy of ATP hydrolysis to transport protons (H+) in exchange for potassium ions (K+). These enzymes consist of a …
H+,K+-ATPase - PubMed
The H+,K+-ATPases comprise a group of integral membrane proteins that belong to the X+,K+-ATPase subfamily of P-type cation-transporting ATPases. Although these H+,K+-ATPase …
Structure and function of H+/K+ pump mutants reveal Na+/K+ …
2022年9月9日 · Here we study primary-active transport via P-type ATPases using functional and structural analyses to demonstrate that four simultaneous residue substitutions transform the …
- 一些您可能无法访问的结果已被隐去。显示无法访问的结果