Effects of Growth Hormone on Bone - PubMed
GH deficiency leads to decreased bone turnover, delayed statural growth in children, low bone mass, and increased fracture risk in adults. GH replacement improves adult stature in GH deficient children, increases bone mineral density (BMD) in adults, and helps to optimize peak bone acquisition in patients, during the transition from adolescence ...
Effects of Growth Hormone on Bone - ScienceDirect
2016年1月1日 · Describe the effects of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) on the skeleton. The GH and IGF-1 axis has pleiotropic effects on the skeleton throughout the lifespan by influencing bone formation and resorption.
Growth hormone: does it have a therapeutic role in fracture ... - PubMed
Results: Current evidence suggests a positive role of GH on fracture healing as demonstrated by in vitro studies on osteoblasts, osteoclasts and the crosstalk between the two. Animal studies have demonstrated a number of factors influencing the effect of GH in vivo such as dose, timing and method of administration.
Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis
Growth hormone (GH) and insulin-like growth factor (IGF-1) are fundamental in skeletal growth during puberty and bone health throughout life. GH increases tissue formation by acting directly and indirectly on target cells; IGF-1 is a critical mediator of bone growth.
The influence of growth hormone deficiency on bone health and ...
The effect of growth hormone and other hormones on bone. Eventually, growth hormone action leads to an increase in linear bone growth, accumulation of bone mineral content (BMC) and preservation of peak bone mass. Growth hormone deficiency (GHD) may lead to growth impairment in children and prevent young adults from reaching peak bone mass.
Growth hormone and bone: a basic perspective | Pituitary
2024年10月30日 · Growth hormone is fundamental for growth during childhood and for maintaining bone mass and homeostasis in the adults. GH deficiency causes decreased bone growth and osteopenia, whereas GH excess causes …
The Long-Term Effects of Growth Hormone Replacement on Bone …
Growth hormone (GH) affects bone metabolism directly by binding to the GH receptor (GHR) or indirectly by insulin-like growth factor-1 (IGF-1). The anabolic effect of RH and IGF-1 is manifested by stimulation of bone proliferation, wherein linear bone growth is promoted by activation of epiphyseal pre-chondrocytes.
Growth Hormone and Bone* | Endocrine Reviews - Oxford …
1998年2月1日 · Recent studies, in both animals and humans, have demonstrated that GH exerts potent effects on bone remodeling. In this article we will discuss the role of GH in the process of bone growth until peak bone mass is achieved and present evidence that an increased endogenous production of GH or treatment with GH might increase bone mass in adults.
Effects of Growth Hormone Replacement Therapy on Bone …
2013年4月17日 · Our meta-analysis suggested that growth hormone replacement therapy could have beneficial influence on bone mineral density in growth hormone deficient adults, but, in some subject populations, the influence was not evident.
Growth hormone and bone - PubMed
Recent findings: Growth hormone deficiency is associated with low bone mass in children and adults, in addition to its well established impact on growth. Although GH and insulin-like growth factor I have direct skeletal actions, it is also possible that disordered parathyroid hormone secretion or effect may mediate some of the deleterious ...
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