Physostigmine: Uses, Interactions, Mechanism of Action
2005年6月13日 · Physostigmine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor which effectively increases the concentration of acetylcholine at the sites of cholinergic transmission. Physostigmine is used to treat glaucoma.
Physostigmine - Wikipedia
Physostigmine (also known as eserine from éséré, the West African name for the Calabar bean) is a highly toxic parasympathomimetic alkaloid, specifically, a reversible cholinesterase inhibitor. It occurs naturally in the Calabar bean and the fruit of the Manchineel tree.
Physostigmine - an overview | ScienceDirect Topics
Physostigmine is a reversible cholinesterase inhibitor that helps prolong the activity of acetylcholine in the body. It is known for its use in treating glaucoma and for stimulating both nicotinic and muscarinic receptors, leading to pupil contraction and ciliary muscle fiber stimulation.
Physostigmine | C15H21N3O2 | CID 5983 - PubChem
Physostigmine is a carbamate ester and an indole alkaloid. It has a role as a miotic, an EC 3.1.1.8 (cholinesterase) inhibitor and an antidote to curare poisoning. A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva.
Physostigmine - SpringerLink
2016年10月12日 · Physostigmine salicylate (Antilirium®) is a short-acting, lipid-soluble, nonselective, carbamate cholinesterase (ChE) inhibitor used to increase acetylcholine (ACh) concentrations at cholinergic receptors and most commonly employed in the treatment of anticholinergic-induced delirium.
Physostigmine - an overview | ScienceDirect Topics
One useful modification to the structure of physostigmine has been the replacement of the methyl group of carbamate moiety by aliphatic alkyl group or phenyl group. It leads to the derivatives: epastigmine and fenserine.
(PDF) The Pharmacology of Physostigmine - ResearchGate
2006年6月7日 · Physostigmine was first synthesized in 1935. The gen- of the enzymes AChE and butyrylcholinesterase (BuChE). Physostigmine exerts a. residue to the enzyme’s active site. Spontaneous hydrolysis...
Physostigmine - an overview | ScienceDirect Topics
Physostigmine, also called eserine, is a N-monomethyl carbamate isolated from the Calabar bean (Physostigma venenosum Balfour) by Jobst and Hesse (1864) and de novo synthesized by Julian and Pikl (1935). Physostigmine reversibly inhibits AChE in mammalian peripheral tissues and in the brain (Deyi et al., 1981; Harris and Stitcher, 1984).
Physostigmine - SpringerLink
2024年1月1日 · Antimuscarinic toxicity and glaucoma are the two conditions that physostigmine is most frequently used to manage and treat. It is a reversible cholinergic drug, a tertiary amine, most commonly used to manage and treat glaucoma and antimuscarinic toxicity.
Physostigmine - AMBOSS
An acetylcholinesterase inhibitor that prevents the breakdown of acetylcholine, which leads to accumulation in the synaptic cleft. Used to treat severe anticholinergic toxicity.