GLUT4 - Wikipedia
Glucose transporter type 4 (GLUT4), also known as solute carrier family 2, facilitated glucose transporter member 4, is a protein encoded, in humans, by the SLC2A4 gene. GLUT4 is the insulin-regulated glucose transporter found primarily in adipose tissues and striated muscle (skeletal and cardiac).
GLUT4 traffic control - Nature
Jun 17, 2021 · Identification of GLUT4 as a unique glucose transporter whose subcellular localization is regulated by insulin raised questions about the physiological implications of these trafficking events.
Structure, function and regulation of mammalian glucose …
Jun 26, 2020 · GLUT4-mediated glucose transport into the major tissues of fat, muscle and heart is of vital importance and reductions in signalling to this process lead to insulin resistance. Transgenic mouse models of diabetes in which GLUT4 expression is increased in muscle have improvements in whole body glucose homeostasis .
GLUT4 - diff
Sep 5, 2011 · GLUT4 is one of 13 sugar transporter proteins (GLUT1- GLUT12, and HMIT) encoded in the human genome that catalyzes hexose transport across cell membranes through an ATP-independent, facilitative diffusion mechanism. GLUT4 is highly espresse in adipose tissue and skeletal muscle.
Structural and Functional Evolution of Glucose Transporter 4 (GLUT4…
Jun 18, 2014 · In mammals, GLUT4 is mainly expressed in insulin-sensitive tissues, namely skeletal and cardiac muscle and adipose tissue. In skeletal muscle, GLUT4 is the main transporter expressed and it has been estimated that it accounts for approximately 70% of the basal glucose transport in this tissue (reviewed in ).
Mechanisms Regulating GLUT4 Transcription in Skeletal Muscle
Nov 18, 2013 · The glucose transporter 4 (GLUT4) plays a key role in glucose uptake in insulin target tissues. This transporter has been extensively studied in many species in terms of its function, expression and cellular traffic and complex mechanisms are involved in its regulation at many different levels.
Glucose transporters in adipose tissue, liver, and skeletal muscle …
Jun 26, 2020 · GLUT4: the workhorse for insulin- and contraction-responsive glucose transports in skeletal muscle and adipocytes. GLUT4 is the most abundant glucose transporter in skeletal muscle and has been considered to be rate limiting for glucose uptake and metabolism, at least in the resting state of the muscle [131, 148].
GLUT4 Code | Molecular Endocrinology | Oxford Academic
Feb 1, 2008 · The GLUT4 Trafficking Itinerary GLUT4 trafficking can be dissected into six discreet steps as shown: budding [biogenesis of GLUT4 storage vesicles (GSVs)], transport, tethering, docking, fusion and endocytosis.
Molecular Dynamics Simulation Studies of GLUT4: Substrate-Free …
Dec 3, 2010 · Glucose transporter 4 (GLUT4) is an insulin facilitated glucose transporter that plays an important role in maintaining blood glucose homeostasis. GLUT4 is sequestered into intracellular vesicles in unstimulated cells and translocated to …
GLUT4 On the move | Biochemical Journal | Portland Press
Feb 11, 2022 · The concept of two phases of the GLUT4 trafficking response to insulin, and of insulin signalling increasing GLUT4 exocytosis rates, are consistent with experimental data from total internal reflectance fluorescence microscopy (TIRF-M).
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