Furin - Wikipedia
Furin is a protease, a proteolytic enzyme activated by substrate presentation that in humans and other animals is encoded by the FURIN gene. Some proteins are inactive when they are first synthesized, and must have sections removed in order to become active. Furin cleaves these sections and activates the proteins.
弗林蛋白酶 - 百度百科
弗林蛋白酶(Furin)是真核生物细胞中一种重要的内切蛋白酶.Furin能识别特定的氨基酸序列,在 内质网-高尔基体 中经两次自剪切活化后,对分泌途径中许多重要的多肽和蛋白的前体进行剪切加工,使之具有生物活性.Furin底物广泛,包括大多数的 肽类激素 、许多生长因子 ...
Furin at the cutting edge: From protein traffic to ... - Nature
2002年10月1日 · Furin is a ubiquitous proprotein convertase that cleaves substrates at the consensus sequence –Arg–X–Lys/Arg–Arg ↓ –. In exceptional cases, –Lys/Arg–X–X–X–Lys/Arg–Arg ↓ – is cleaved. Furin has...
弗林蛋白酶 - 维基百科，自由的百科全书
弗林蛋白酶由 15號染色體 上的FUR基因編碼，具有P1、P1A與P1B等三個 啟動子，皆使用不同的 轉錄 起始位點，產生 5'UTR 不同但 編碼區域 相同的 mRNA，其中P1A與P1B為持續表現的 看家基因 啟動子，P1則可被一些 細胞激素 活化，與 C/EBPβ （英语：CCAAT-enhancer-binding proteins） 轉錄因子 結合而啟動轉錄 [9]。 弗林蛋白酶有和其他第一型穿膜蛋白一樣有一 N端 信號肽 會在轉譯時被切除，另外N端還有一長83個氨基酸的 結構域 為此蛋白正常 折疊 所需，C端 …
FURIN AT THE CUTTING EDGE: FROM PROTEIN TRAFFIC TO …
Furin catalyses a simple biochemical reaction – the proteolytic maturation of proprotein substrates in the secretory pathway. But the simplicity of this reaction belies furin's broad and important roles in homeostasis, as well as in diseases ranging from Alzheimer's disease and cancer to anthrax and Ebola fever.
FURIN Gene - GeneCards | FURIN Protein | FURIN Antibody
2024年10月1日 · FURIN (Furin, Paired Basic Amino Acid Cleaving Enzyme) is a Protein Coding gene. Diseases associated with FURIN include Cerebral Amyloid Angiopathy, Itm2b-Related, 1 and Anthrax Disease. Among its related pathways are ADORA2B mediated anti-inflammatory cytokines production and HIV Life Cycle.
Furin‐mediated protein processing in infectious diseases and cancer
In this review, we summarise our current knowledge of furin‐mediated protein processing in health and disease with a focus on the role of furin in viral protein processing. Furthermore, we describe cellular mechanisms regulating furin activity at the transcriptional and post‐transcriptional level.
Furin at the cutting edge: from protein traffic to ... - PubMed
This review summarizes various features of furin--its structural and enzymatic properties, intracellular localization, trafficking, substrates, and roles in vivo. Furin catalyses a simple biochemical reaction--the proteolytic maturation of proprotein substrates in the secretory pathway.
Bi-cycling the furin pathway: from TGN localization to pathogen ...
1999年1月1日 · Furin is a secretory pathway endoprotease that catalyses the maturation of a strikingly diverse group of proprotein substrates, ranging from growth factors and receptors to pathogen proteins, in multiple compartments within the trans-Golgi network (TGN)/endosomal system. This review focuses on recent developments in the biochemistry and cell ...
Furin - an overview | ScienceDirect Topics
Furin is a type I transmembrane protein composed of a signal peptide, a propeptide terminating in an endoproteolytic cleavage site comprised of a cluster of basic residues, a subtilisin-like catalytic domain, a middle domain (also called P-domain), and a cysteine-rich domain, followed by a C-terminal transmembrane anchor and a cytosolic tail ...