Three-dimensional characterization of fibroblast foci in idiopathic ...
In idiopathic pulmonary fibrosis (IPF), the fibroblast focus is a key histological feature representing active fibroproliferation. On standard 2D pathologic examination, fibroblast foci are considered small, distinct lesions, although they have been proposed to form a highly interconnected reticulum as the leading edge of a “wave” of fibrosis.
Fibroblastic Foci - CHEST
In a third publication, Flaherty et al 9 found that there were fewer fibroblastic foci in patients with UIP as part of rheumatologic diseases than in those with IPF, and this is in keeping with the well-recognized better survival of the former. What can be inferred from these observations?
Idiopathic pulmonary fibrosis: an epithelial/fibroblastic cross …
2001年10月11日 · It has been suggested that IPF is characterized by a sequence of events that start with alveolar epithelial micro-injuries followed by the formation of fibroblastic foci and result in an exaggerated deposition of extracellular matrix, which drives the destruction of the lung parenchyma architecture [5,6].
Fibroblastic foci, covered with alveolar epithelia exhibiting ...
2016年12月12日 · Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease of unknown cause. IPF has a distinct histopathological pattern of usual interstitial...
Fibroblast Foci Are Not Discrete Sites of Lung Injury or Repair
2006年9月9日 · Background: Usual interstitial pneumonia (UIP), the pathologic correlate of idiopathic pulmonary fibrosis, contains characteristic discrete areas of fibroblasts, myofibroblasts, and newly formed collagen, termed “fibroblast foci.” These lesions are argued to represent isolated sites of recurrent acute lung injury and suggested to be the ...
Idiopathic pulmonary fibrosis: immunohistochemical analysis provides ...
Histological disease status in IPF lungs was explored in relation to target marker expression levels in, (i) regions of hyperplastic ATII cells and (ii) cells within the fibroblastic foci. The number of established fibroblastic foci present in IPF lung tissue relates to disease activity and an increased rate of disease progression [2-4].
Lung Fibroblasts, Aging, and Idiopathic Pulmonary Fibrosis
2016年5月7日 · In situ, fibroblasts differentiate to myofibroblasts and organize in distinct clusters called fibroblastic foci, secreting exaggerated amounts of extracellular matrix (ECM) components that accumulate in the interstitial and alveolar spaces with consequent destruction of the lung parenchyma (2–4).
Relationship between fibroblastic foci profusion and high …
2015年9月24日 · In patients with fibrotic lung disease, profusion of fibroblastic foci is strikingly related to the severity of traction bronchiectasis, particularly in IPF and CHP. This may explain the growing evidence that traction bronchiectasis is a predictor of mortality in …
miRNA Expression in Fibroblastic Foci within Idiopathic …
The current study used laser microdissection to collect fibroblastic foci (FF), the key pathologic lesion in IPF, isolated miRNAs, and compared their expression levels with those found in whole IPF lung tissue and/or in vitro cultured fibroblast from IPF or normal lungs.
Three-dimensional characterization of fibroblast foci in
2016年4月21日 · In idiopathic pulmonary fibrosis (IPF), the fibroblast focus is a key histological feature representing active fibroproliferation. On standard 2D pathologic examination, fibroblast foci are considered small, distinct lesions, although they have been proposed to form a highly interconnected reticulum as the leading edge of a "wave" of fibrosis.